COX
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB02230 | Valdecoxib | 181695-72-7 | Valdecoxib is a potent COX inhbitor that selectively inhibitors COX-2 with IC50 of 5 nM. |
| FB00755 | Ufenamate | 67330-25-0 | Ufenamate is a COX inhibitor, used as a topical analgesic. |
| FB00424 | Tribenoside | 10310-32-4 | Tribenoside is a vasoprotective and a mixture of the α- und β-anomers. |
| FB00280 | Tolfenamic Acid | 13710-19-5 | Tolfenamic acid is a selective COX2 inhibitor with IC50 of 13.49 μM, it's a non-steroidal anti-inflammatory drugs (NSAIDs). |
| FB09692 | Tenoxicam | 59804-37-4 | Tenoxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. |
| FB09633 | Sulindac | 38194-50-2 | Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) and is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis. |
| FB03825 | SC58125 | 162054-19-5 | SC 58125 is a selective, time-dependent, and irreversible cyclooxygenase-2 (Cox-2) inhibitor that displays anti-inflammatory properties. |
| FB01175 | Salicylic acid | 69-72-7 | Salicylic acid, a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity. |
| FB09153 | Salicin | 138-52-3 | Salicin is a non-selective COX-1 and COX-2 inhibitor, it is a phenol β-glycosid isolated and purified from the peel of Salix alba L.and shows anti-inflammatory effects. |
| FB03039 | Propyphenazone | 479-92-5 | Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. |
| FB00492 | Piroxicam | 36322-90-4 | Piroxicam is a selective COX1 inhibitor with anti-inflammatory effects. |
| FB01470 | Phenacetin | 62-44-2 | Phenacetin is a non-opioid analgesic used in treatment of pain-relieving and fever-reducing. |
| FB06395 | Perilloxin | 263249-77-0 | Perilloxin, a natural product isolated and purified from the stems of Perilla frutescens var. acuta., possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 mM. |
| FB03028 | Parecoxib Sodium | 198470-85-8 | Parecoxib Sodium, a water-soluble and injectable prodrug of valdecoxib, is a COX2 inhibitor used for the short-term treatment of postoperative pain in adults. |
| FB00251 | Parecoxib | 198470-84-7 | Parecoxib is a potent and selective COX2 inhibitor. |
| FB06797 | Oxaprozin | 21256-18-8 | Oxaprozin is a COX inhibitor with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, it's a NSAID used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. |
| FB07710 | NS-398 | 123653-11-2 | NS-398 is a selective inhibitor of COX2 with IC50s of 75 and 1.77 μM for human recombinant COX1 and 2 respectively. |
| FB07895 | Nimesulide | 51803-78-2 | Nimesulide is a COX2 selective inhibitor with IC50 of 26 μM. |
| FB07422 | Nepafenac | 78281-72-8 | Nepafenac is a selective COX2 inhibitor and is prodrug of amfenac used in the treatment of pain and inflammation associated with cataract surgery. |
| FB07145 | Naproxen | 22204-53-1 | Naproxen is a COX inhibitor for COX1/2 with IC50 of 8.7 and 5.2 μM, respectively. |
| FB07209 | Naproxen Sodium | 26159-34-2 | Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively. |
| FB07122 | Nabumetone | 42924-53-8 | Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) and its active metabolite inhibits the COX. |
| FB08867 | Meloxicam | 71125-38-7 | Meloxicam is a nonsteroidal anti-inflammatory agent with selectivity for COX2 (IC50 = 11.8 μM) over COX1 (IC50 = 143 μM) in in vitro assays. It shows potent anti-inflammatory, antipyretic, and analgesic effects with low gastrointestinal toxicity. |
| FB03909 | Mefenamic Acid | 61-68-7 | Mefenamic Acid is an inhibitor of COX2 with anti-inflammatory properties, it's a non-steroidal anti-inflammatory agent. |
| FB03904 | Meclofenamate Sodium | 6385-02-0 | Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. |
| FB03566 | Loxoprofen | 68767-14-6 | Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and propionic acid derivative. |
| FB03560 | Lornoxicam | 70374-39-9 | Lornoxicam is a COX inhibitor with IC50 of 5 nM and 8 nM for COX1 and 2 respectively. It's a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of various types of pain. |
| FB01776 | Loganin | 18524-94-2 | Loganin is a naturally occuring iridoid glycoside with antioxidant, hepatoprotective and neuroprotective effects, as well as a COX-1 inhbitor with IC50 value of 3.55 µM, suppressing the formation of TNF-α, and diminishing the production of nitric oxide. |
| FB08696 | Licofelone | 156897-06-2 | Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis. |
| FB03105 | Ketorolac Tromethamine | 74103-07-4 | Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively. |
| FB03104 | Ketoprofen | 22071-15-4 | Ketoprofen is a dual COX1/2 inhibitor with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively, and used as a nonsteroidal anti-inflammatory drug (NSAID) to treat arthritis-related inflammatory pains. |
| FB03453 | Indomethacin | 53-86-1 | Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling. |
| FB02920 | Indomethacin Farnesil | 85801-02-1 | Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug indometacin. |
| FB02841 | Ibuprofen | 15687-27-1 | Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively, and is used for pain relief, fever reduction and for reducing swelling. |
| FB03627 | Hexahydrocurcumin | 36062-05-2 | Hexahydrocurcumin is a natural compound which posesses anticancer and anti-inflammatory activities and is a selective COX-2 inhibitor. |
| FB02174 | Guacetisal | 55482-89-8 | Guacetisal is a drug that has been used to treat inflammatory respiratory diseases. |
| FB01841 | Flunixin Meglumine | 42461-84-7 | Flunixin meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. |
| FB03224 | Flufenamic Acid | 530-78-9 | Flufenamic Acid is a COX inhibitor and prevents formation of prostaglandins, binds to and reduce the activity of prostaglandin F synthase and activate TRPC6, it is a NSAID drug. |
| FB00074 | Firocoxib | 189954-96-9 | Firocoxib is a potent and selective COX2 inhibitor with IC50 of 0.13 μM. |
| FB01784 | Fenoprofen Calcium | 34597-40-5 | Fenoprofen Calcium is COX-1/2 inhibitor used as an NSAID. It can also inhibit fatty acid oxidation and acts as a peroxisome proliferator. |
| FB01768 | Fenbufen | 36330-85-5 | Fenbufen is a phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug. |
| FB01712 | Etoricoxib | 202409-33-4 | Etoricoxib is a selective COX2 inhibitor with IC50 of 1.1 ± 0.1 μM and 116 ± 8 μM for COX1. |
| FB07326 | Diflunisal | 22494-42-4 | Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a cyclooxygenase Inhibitor. |
| FB07180 | Diclofenac Sodium | 15307-79-6 | Diclofenac sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation. |
| FB10537 | Diclofenac | 15307-86-5 | Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. |
| FB09389 | CGP 45840B | 15307-81-0 | CGP 45840B is a non-selective reversible and competitive inhibitor of COX, used as an anti-inflammatory drug and an analgesic agent. |
| FB08449 | ATB-346 | 1226895-20-0 | ATB-346 is a hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. |
| FB06516 | Asaronaldehyde | 4460-86-0 | Asaronaldehyde is a COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1, it's a natural product isolated and purified from the rhizoma of Acorus tatarinowii Schott. |
| FB07819 | Amfenac Sodium Monohydrate | 61618-27-7 | Amfenac Sodium Monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively. |
| FB05986 | Alstoyunine E | 1188932-15-1 | Alstoyunine E is a natural product isolated and purified from the herbs of Alstonia yunnanensis showing selective inhibition of Cox-2 (> 75%). |