Proteasome
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00444 | VR23 | 1624602-30-7 | VR23 is a small molecule inhibitor which targets β2 of the 20S proteasome with IC50 of 1 nM and can induce apoptosis of cancer cells via cyclin E–mediated centrosome amplification. |
| FB12106 | TY-51469 | 603987-59-3 | TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively. |
| FB09985 | TIR-199 | 1514925-83-7 | TIR-199, a natural product-derived syrbactin structural analog which covalently binds each of the three catalytic subunits (β1, β2, and β5) and revealed key interaction sites, and is used for the treatment of multiple myeloma and other forms of cancer. |
| FB12085 | Rpn11-IN-1 | 2084867-65-0 | Rpn11-IN-1 is a potent and selective inhibitor of proteasome subunit Rpn11 with an IC50 of 390 nM. |
| FB16793 | 3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one | 145888-79-5 | PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. It inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites, with anticancer activity. |
| FB11810 | Proteasome-IN-1 | 374080-21-4 | Proteasome-IN-1 is a proteasome inhibitor extracted from patent WO 2013142376 A1. |
| FB08682 | PI-1840 | 1401223-22-0 | PI-1840 is a potent and selective inhibitor for chymotrypsin-like (CT-L) (IC50 value = 27 ± 0.14 nM) over trypsin-like and peptidylglutamyl peptide hydrolyzing (IC50 values > 100 μM) activities of the proteasome. |
| FB08338 | ONX-0914 | 960374-59-8 | ONX-0914 is 20- to 40-fold more selective for LMP7 over the next most sensitive sites, β5 or LMP2. |
| FB06970 | Oprozomib | 935888-69-0 | ONX 0912 is an inhibitor of proteasome that targets the chymotrypsin-like activity of the 20S proteasome subunits β5 (IC50 = 36 nM) and LMP7 (IC50 = 82 nM). |
| FB02901 | MLN9708 | 1201902-80-8 | MLN9708 is the prodrug of MLN2238 which is an inhibitor of the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM, 0.93 nM, respectively. |
| FB05934 | MG-132 | 133407-82-6 | MG-132 is an inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 nM). |
| FB08133 | Marizomib | 437742-34-2 | Marizomib, a natural product isolated and purified from marine bacteria Salinispora tropica and Salinispora arenicola, inhibits 20S proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients. |
| FB00107 | Ixazomib | 1072833-77-2 | Ixazomib selectively inhibits the chymotrypsin-like proteolytic (β5) site of 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. |
| FB00239 | Ixazomib Citrate | 1239908-20-3 | Ixazomib citrate is the citrate form of ixazomib which is an inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 of 3.4 nM. |
| FB10922 | GNF-6702 | 1799329-72-8 | GNF-6702 is a proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness. |
| FB12542 | Gliotoxin | 67-99-2 | Gliotoxin is an inhibitor of 20S proteasome and acts as immunosuppressive agent. |
| FB16057 | Fulacimstat | 1488354-15-9 | Fulacimstat is a chymase inhibitor with IC50 values of 4nM and 3 nM for human and hamster chymase enzyme, respectively. |
| FB08107 | Epoxomicin | 134381-21-8 | Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. |
| FB00108 | Delanzomib | 847499-27-8 | Delanzomib is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. |
| FB11984 | Clasto-Lactacystin β-lactone | 154226-60-5 | Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor. |
| FB02540 | Celastrol | 34157-83-0 | Celastrol is an inhibitor of HSP90 with antioxidant and anti-inflammatory activities. |
| FB01563 | Carfilzomib | 868540-17-4 | Carfilzomib is an irreversible proteasome inhibitor with IC50 of < 5 nM and can treat relapsed and refractory multiple myeloma. |
| FB10774 | Capzimin | 2084868-04-0 | Capzimin shows > 5-fold selectivity for Rpn11 over the related JAMM proteases and > 2 logs selectivity over several other metalloenzymes. |
| FB04399 | Bortezomib | 179324-69-7 | Bortezomib is an inhibitor of 20S proteasome with Ki of 0.6 nM. |
| FB12254 | AM 114 | 856849-35-9 | AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome with IC50 ~ 1 μM. |
| FB11135 | Aclarubicin HCl | 75443-99-1 | Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| FB12586 | (R)-MG 132 | 1211877-36-9 | (R)-MG132 can act as an inhibitor of proteasome and be used in ubiquitination assay. |