Complement System
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB16908 | SB 290157 Trifluoroacetate | 1140525-25-2 | SB 290157 Trifluoroacetate is the trifluoroacetate form of SB 290157. SB 290157 is a competitive and selective C3aR (anaphylatoxin C3a receptor) antagonist. It blocked C3a-induced C3aR internalization in a concentration-dependent manner and C3a-induced Ca(2+) mobilization in RBL-C3aR cells and human neutrophils with IC(50)s of 27.7 and 28 nM, respectively. |
| FB11766 | PMX 205 Trifluoroacetate | N/A | PMX 205 Trifluoroacetate is a potent complement C5a receptor (C5aR; CD88) antagonist. |
| FB16772 | Danicopan | 1903768-17-1 | Danicopan is selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. It has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
| FB04089 | BCX 1470 Methanesulfonate | 217099-44-0 | BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. |
| FB04088 | BCX 1470 | 217099-43-9 | BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. |