Transferase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB04041 | Tipifarnib S-Enantiomer | 192185-71-0 | Tipifarnib S-enantiomer is the enantiomer of tipifarnib, a potent and specific farnesyltransferase inhibitor with an IC50 of 0.6 nM. |
| FB00244 | Tipifarnib | 192185-72-1 | Tipifarnib is an inhibitor of farnesyltransferase with IC50 of 0.6 nM. |
| FB12087 | SHIN1 | 2146095-85-2 | SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. |
| FB03831 | Salirasib | 162520-00-5 | Salirasib is an inhibitor of prenylated protein methyltransferase (PPMTase) with Ki of 2.6 μM and can inhibit the methylation of Ras. |
| FB12084 | RP-64477 | 135239-65-5 | RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT). |
| FB11038 | PF-9366 | 72882-78-1 | PF-9366 is an allosteric inhibitor of Mat2A that binds an allosteric site on Mat2A that overlaps with the binding site for the Mat2A regulator, Mat2B, targeting S-adenosylmethionine biosynthesis, with IC50 of 420 nM and Kd of 170 nM, respectively. |
| FB00553 | Perillyl Alcohol | 536-59-4 | Perillyl Alcohol is a naturally occurring monocyclic terpene which can inhibit farnesyl transferase and geranylgeranyl transferase. |
| FB09813 | O6-Benzylguanine | 19916-73-5 | O6-Benzylguanine is an inactivator of O6-alkylguanine DNA alkyltransferase (AGT) and can prevent the repair of DNA damage induced by chemotherapeutics. It induces apoptosis and cell death. |
| FB16637 | Tris DBA | 51364-51-3 | N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. Also used as a cyclization catalyst. |
| FB15848 | Myriocin | 35891-70-4 | Myriocin is a potent SPT (serine palmitoyltransferase) inhibitor. |
| FB12051 | MAT2A Inhibitor | 2201057-10-3 | MAT2A inhibitor is a methionine adenosyltransferase 2A (MATA2) inhibitor. |
| FB11343 | Manumycin A | 52665-74-4 | Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. |
| FB03554 | Lonafarnib | 193275-84-2 | Lonafarnib is a FPTase inhibitor. It can inhibit H-ras (IC50 = 1.9 nM), K-ras-4B (IC50 = 5.2 nM) and N-ras (IC50 = 2.8 nM). |
| FB17658 | Lifibrate | 22204-91-7 | Lifibrate is an inhibitor of cholinephosphotransferase (CPT), phosphatidyl-N-methylethanolamine N-methyltransferase (PME-NMT), and phosphatidyl-N,N-dimethylethanolamine N-methyltransferase (PDE-NMT). |
| FB09942 | LB42708 | 226929-39-1 | LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively. |
| FB15492 | L-Glutamic acid γ-(p-nitroanilide) | 7300-59-6 | L-Glutamic acid γ-(p-nitroanilide) is a substrate for γ-glutamyl transpeptidase. |
| FB15246 | L-Glutamic acid γ-(p-nitroanilide) HCl | 67953-08-6 | L-Glutamic acid γ-(p-nitroanilide) HCl is a substrate for GGT (gamma-glutamyltransferase), which is a transferase that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor. |
| FB07088 | L-778123 HCl | 253863-00-2 | L-778123 HCl is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. |
| FB17887 | Isoastilbin | 54081-48-0 | Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research. |
| FB00092 | Ibiglustat | 1401090-53-6 | Ibiglustat is a potent and selective glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. |
| FB16644 | LY 78335 HCl | 39959-66-5 | High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model. |
| FB18077 | GOT1 inhibitor 2c | 732973-87-4 | GOT1 inhibitor 2c is a GOT1 inhibitor with IC50 value of 8.2μM. |
| FB10184 | GGTI298 Trifluoroacetate | 1217457-86-7 | GGTI298 trifluoroacetate is geranylgeranyltransferase I inhibitor. It shows supression of the G1 phase of the cell cycle and induction of apoptosis. |
| FB15243 | GGTI-2418 | 501010-06-6 | GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor. GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors[1]. |
| FB02086 | Geraniol | 106-24-1 | Geraniol is an inhibitor of glutathion S transferase with anticarcinogenic property. |
| FB17752 | GDP-Mannose disodium salt | 148296-46-2 | GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) . |
| FB11039 | FTI-277 Trifluoroacetate | 1217447-06-7 | FTI-277 trifluoroacetate is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. |
| FB03979 | FTI-277 | 170006-73-2 | FTI-277 is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. |
| FB04021 | FTI-277 HCl | 180977-34-8 | FTI-277 HCl is an inhibitor of farnesyl transferase (FTase) and a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. |
| FB01449 | FTI 276 | 170006-72-1 | FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 and 0.5 nM for Plasmodium falciparum and human. |
| FB16530 | FTI-2148 | 251577-09-0 | FTI-2148 is a RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) inhibitor with IC50s of 1.4 nM and 1.7 μM for FT-1 and GGT-1, respectively. |
| FB01506 | EPZ015666 | 1616391-65-1 | EPZ015666 is a selective inhibitor of PRMT5 with Ki of 5 nM. |
| FB11994 | E-5324 | 141799-76-0 | E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC50s of 44 to 190 nM. |
| FB11520 | CP-609754 | 1190094-64-4 | CP-609754, also known as CP-609,754, LNK 754 and OSI 754, is a selective inhibitor of arnesyltransferase with potential anticancer activity. |
| FB16280 | Benzoyleneurea | 86-96-4 | Benzoyleneurea scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. |
| FB07874 | Azaserine | 115-02-6 | Azazerine is a competitive inhibitor of glutamine amidotransferase, a key enzyme responsible for glutamine metabolism. |
| FB15553 | ATR-101 | 133825-80-6 | ATR-101 is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC). |
| FB10836 | ATR-101 HCl | 133825-81-7 | ATR-101 HCl is a selective inhibitor of acyl coenzyme A:cholesterol acyltransferase (ACAT1), it is in clinical development for the treatment of adrenocortical carcinoma (ACC). |
| FB11206 | Antimalarial C86(+) | N/A | Antimalarial C86(+) is an antimalarial inhibitor targeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy. |
| FB12962 | Aminooxyacetic acid hemihydrochloride | 2921-14-4 | Aminooxyacetic acid hemihydrochloride is an inhibitor of malate-aspartate shuttle (MAS) and also exhibits suppression of GABA-T. |
| FB10456 | Amentoflavone | 1617-53-4 | Amentoflavone is an inhibitor of human UDP-glucuronosyltransferases with anti-inflammatory, antioxidative, and neuroprotective effects and it can be isolated from the seeds of Ginkgo biloba L. Amentoflavone inhibited SARS-CoV 3CL(pro) with IC50 value of 8.3μM. |
| FB11956 | AGI-25696 | 2201066-35-3 | AGI-25696 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo. |
| FB11955 | AGI-24512 | 2201066-53-5 | AGI-24512 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-24512 blocks growth of MTAP-deleted cancer cells in vitro. |
| FB15223 | MAT2A Inhibitor 1 | 13299-99-5 | AG-270 is a potent and orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with potential antineoplastic activity. |
| FB06133 | (R)-(+)-Etomoxir Sodium | 828934-41-4 | (R)-(+)-etomoxir sodium salt is inhibitor of carnitine palmitoyltransferase I (CPT1) and can reduce β-oxidation in mitochondria. It shows inhibition of cardiolipin biosynthesis. |
| FB16015 | FGTI-2734 | 1247018-19-4 |