ROCK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10238 | ZINC00881524 | 557782-81-7 | ZINC00881524 is an inhibitor of ROCK. |
| FB05164 | Y-33075 2HCl | 173897-44-4 | Y-39983 HCl is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM. |
| FB04058 | Y-33075 | 199433-58-4 | Y-33075 is potent and selective p160 ROCK inhibitor with an Ki value of 0.14 μM, > 200 fold selectivity for p160ROCK than PKC, cAMP-dependent protein kianse and Mypsin light-chain kinase. |
| FB00936 | Y-27632 | 146986-50-7 | Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively. |
| FB01623 | Y-27632 2HCl | 129830-38-2 | Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits > 200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| FB01703 | Thiazovivin | 1226056-71-8 | Thiazovivin is a ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation. |
| FB01150 | SR-3677 | 1072959-67-1 | SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays, and its IC50 for ROCK-I is 56 ± 12 nM. |
| FB01583 | SLx-2119 | 911417-87-3 | SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM, which is over 200 fold selecivity over ROCK1 (IC50 =24 μM). |
| FB06950 | SAR407899 | 923359-38-0 | SAR407899 is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
| FB03131 | SAR407899 HCl | 923262-96-8 | SAR407899 HCl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
| FB12082 | ROCK2-IN-2 | 1995065-79-6 | ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM. |
| FB06873 | ROCK Inhibitor | 867017-68-3 | ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively. |
| FB08671 | RKI-1447 | 1342278-01-6 | RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2, with IC50 of 14.5 nM and 6.2 nM, respectively, and has anti-invasive and antitumor activities. |
| FB01064 | RKI-1313 | 1342276-76-9 | RKI-1313 is a negative control for RKI-1447 (GLXC-05200) which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. |
| FB02676 | AR-13324 HCl | 1253952-02-1 | Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. |
| FB20292 | Netarsudil | 1254032-66-0 | Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2. |
| FB02332 | LX7101 | 1192189-69-7 | LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24, 1.6 and 10 nM for LIMK1, LIMK2 and ROCK2, respectively and also inhibits PKA with an IC50 less than 1 nM. |
| FB01566 | K-115 | 223645-67-8 | K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 = 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension. |
| FB01565 | K-115 HCl 2H2O | 887375-67-9 | K-115 HCl is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. |
| FB01496 | Hydroxyfasudil | 105628-72-6 | Hydroxyfasudil, metabolite of Fasudil, is a potent Rho-kinase inhibitor and vasodilator. |
| FB08695 | Hydroxyfasudil HCl | 155558-32-0 | Hydroxyfasudil HCl, metabolite of fasudil, is a potent Rho-kinase inhibitor and vasodilator. |
| FB03412 | H-1152 | 451462-58-1 | H-1152, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. |
| FB08929 | H-1152 2HCl | 871543-07-6 | H-1152 2HCl, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. |
| FB00702 | GSK429286A | 864082-47-3 | GSK429286A selectively inhibits ROCK1 and ROCK2 with the IC50 value of 14 nM and 63 nM, respectively. |
| FB06841 | GSK269962 | 850664-21-0 | GSK269962A is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively), and displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. |
| FB10195 | GSK269962 HCl | 2095432-71-4 | GSK269962 HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
| FB16367 | GSK-25 | 874119-56-9 | GSK-25 is a ROCK1 inhibitor with IC50 value of 6nM. It showed oral bioavailability (49% in rat and 19% in monkey), good half-life (1.8 h in rat and 2.2 h in monkey) and gave a robust 25 mmHg reduction mean arterial pressure in spontaneously hypertensive rats at a single dose of 30 mg/kg. |
| FB12516 | Glycyl-H 1152 2HCl | 913844-45-8 | Glycyl-H 1152 2HCl is a selective Rho-kinase (ROCK) inhibitor with IC50 of 0.0118 μM for ROCKII. |
| FB01730 | Fasudil | 103745-39-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| FB01731 | Fasudil HCl | 105628-07-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| FB02702 | Chroman 1 | 1273579-40-0 | Chroman 1 is a highly potent and selective ROCK II inhibitor. |
| FB12231 | AS 1892802 | 928320-12-1 | AS 1892802 is a potent, ATP-competitive ROCK inhibitor with IC50s of 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively. |
| FB03197 | AR-13324 Mesylate | 2166548-12-3 | AR-13324 mesylate is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter which inhibits kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. |
| FB10256 | AR-13324 Mesylate Analog | N/A | AR-13324 mesylate analog is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter and reduces intraocular pressure (IOP) in normotensive monkey eyes. |