Dopamine Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB11075 | Zicronapine | 170381-16-5 | Zicronapine is an atypical antipsychotic medication. Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors. |
| FB00884 | Veralipride | 66644-81-3 | Veralipride is an antagonist of D2 receptor. It is used for the treatment of menopausal symptoms. |
| FB12831 | Trimethobenzamide HCl | 554-92-7 | Trimethobenzamide HCl is a dopamine D2 receptor antagonist and antiemetic drug. |
| FB00173 | Tiamenidine | 31428-61-2 | Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism. |
| FB16752 | Tavapadon mixture | 1643462-64-9 | Tavapadon mixture is the mixture form of Tavapadon, 1,5-Dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione, while Tavapadon is the pure (-)-1,5-Dimethyl-6-[2-methyl-4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-2,4(1H,3H)-pyrimidinedione. |
| FB19649 | Tavapadon | 1643489-24-0 | Tavapadon is an orally active and highly selective dopamine D1/D5 receptor partial agonist. It may be useful in the treatment of Parkinson's disease and Alzheimer's. |
| FB09636 | Sultopride HCl | 23694-17-9 | Sultopride HCl is a selective antagonist of dopamine D2 receptor |
| FB02292 | ST-836 | 1148156-63-1 | ST-836 is a dopamine receptor ligand and an antiparkinsonian agent. |
| FB03186 | ST-836 HCl | 1415564-68-9 | ST-836 HCl is a dopamine receptor ligand which act as an antiparkinsonian agent. |
| FB17601 | SKF-83566 | 99295-33-7 | SKF-83566 is a potent, blood-brain permeable and orally active dopamine D1/D5 receptor antagonist . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM and attenuates cocaine effects in vivo . |
| FB06270 | SKF-82958 Hydrobromide | 74115-01-8 | SKF-82958 hydrobromide is a D1/D5 receptor full agonist. |
| FB10763 | SKF 83959 Hydrobromide | 67287-95-0 | SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). It may act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. |
| FB16868 | SKF 77434 | 104422-04-0 | SKF 77434 is Dopamine D1 receptor partial agonist. Chronic treatment with SKF 77434 produced dose-dependent effects on cocaine self-administration in Rhesus Monkeys. |
| FB12933 | SCH 23390 HCl | 125941-87-9 | SCH 23390 HCl is an antagonist of dopamine receptor D1 and D5 with Ki of 0.2 nM and 0.3 nM, respectively. |
| FB04087 | SB-277011 | 215803-78-4 | SB-277011 is a potent and delective brain-penetrant dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and < 5.2 for D3, D2, 5-HT1D and 5-HT1B respectively). |
| FB04086 | SB-269652 | 215802-15-6 | SB-269652 is the first drug-like allosteric modulator of the dopamine D2 receptor (D2R) and a chemical probe that can differentiate D2R monomers from dimers or oligomers depending on the observed pharmacology. |
| FB02214 | SB 277011A 2HCl | 1226917-67-4 | SB 277011A 2HCl is a selective brain-penetrant dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and < 5.2 for D3, D2, 5-HT1D and 5-HT1B respectively). |
| FB13000 | Ro 10-5824 2HCl | 189744-94-3 | Ro 10-5824 2HCl is an agonist of dopamine D4 receptor with Ki of 5.2 nM. |
| FB16390 | Raclopride | 84225-95-6 | Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively . |
| FB01930 | rac-Rotigotine HCl | 102120-99-0 | rac-Rotigotine HCl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM. |
| FB11525 | SCH23390 | 87134-87-0 | Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors. |
| FB12601 | PD-168077 | 190383-31-4 | PD168,077 is a dopamine D4 receptor agonist which has a facilitatory effect on memory consolidation. |
| FB12832 | PD 168077 Maleate | 630117-19-0 | PD 168077 maleate is an agonist of D4 dopamine receptor with Ki of 8.7 nM. It can induce synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. |
| FB04854 | Pardoprunox HCl | 269718-83-4 | Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist. |
| FB17995 | Paliperidone palmitate | 199739-10-1 | Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia. |
| FB01637 | NGB 2904 HCl | 189061-11-8 | NGB 2904 is a potent and selective dopamine D3 receptor antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). |
| FB17211 | ML417 | 1386162-69-1 | ML417 is a novel and highly selective D3 dopamine receptor agonist with EC50 value of 38nM. |
| FB10697 | Metoclopramide HCl H2O | 54143-57-6 | Metoclopramide HCl is an antagonist of dopamine D2 receptor that is structurally related to procainamide. It has antiemetic and gastroprokinetic activities. |
| FB15329 | Mesoridazine Besylate | 32672-69-8 | Mesoridazine besylate is a phenothiazine dopamine receptor anatagonist. Mesoridazine besylate is described to demonstrate inhibition for D2DR and D4DR. It has a high affinity for dopamine D4 receptor. Mesoridazine besylate is an antipsychotic agent. |
| FB12866 | Melitracen HCl | 10563-70-9 | Melitracen HCl, a member of anthracenes, is an antagonist of dopamine D1 and D2 receptors. It is used as an antidepressant. |
| FB03002 | Lurasidone | 367514-87-2 | Lurasidone functions as an antagonist of the dopamine D2 and D3 receptors, the serotonin 5-HT2A and 5-HT7 receptors, the α2C-adrenergic receptor, and as a partial agonist of the serotonin 5-HT1A receptor. |
| FB16520 | L-745870 | 158985-00-3 | L-745870 is a high-affinity, selective and orally active human dopamine D4 receptor antagonist with a Ki of 0.43 nM and excellent brain penetration. |
| FB02714 | Iloperidone HCl | 1299470-39-5 | Iloperidone HCl is a D(2)/5-HT(2) receptor antagonistis, which is an atypical antipsychotic for the treatment of schizophrenia symptoms. |
| FB08146 | Haloperidol | 52-86-8 | Haloperidol is an antagonist of dopamine D2-like receptors (D1-D5) and it is used as a typical antipsychotic. |
| FB03276 | Haloperidol HCl | 1511-16-6 | Haloperidol HCl blocks dopamine receptors in in the treatment of schizophrenia, acute psychosis, and delirium. |
| FB11065 | GSK598809 | 863680-45-9 | GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving in humans. |
| FB06828 | GSK163090 | 844903-58-8 | GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for dopamine D2/D3, respectively. |
| FB17659 | Fluphenazine | 69-23-8 | Fluphenazine is a typical antipsychotic used for symptomatic management of psychosis in patients with schizophrenia. |
| FB11067 | FAUC 329 | 474432-48-9 | FAUC 329 is a dopamine D3 receptor ligand showing protective effects against dopamine depletion in a MPTP mouse model of Parkinson's disease. |
| FB01953 | Dexpramipexole 2HCl | 104632-27-1 | Dexpramipexole 2HCl is the HCl form of Dexpramipexole which is a non-ergoline dopamine agonist for treatment of parkinson's disease and restless leg syndrome.Dexpramipexole is an (R)-(+) optical enantiomer of pramipexole. |
| FB10693 | Chlorprothixene | 113-59-7 | Chlorprothixene is an antagonist of multiple receptors including 5-HT2 (Ki = 3.4 nM), D1 (Ki = 18 nM), D2 (Ki = 18 nM), D3 (Ki = 4.56 nM), H1 (Ki = 3.75 nM), muscarinic acetylcholine receptors, α1-Adrenergic. |
| FB11325 | BP897 | 314776-92-6 | BP897 is a partially selective dopamine D3 receptor agonist (Ki = 0.92 nM) that developed for the study of cocaine addiction. |
| FB06294 | Amisulpride HCl | 81342-13-4 | Amisulpride HCl is an antipsychotic drug, which is a selective dopamine antagonist (Ki=2.8 nM D2 receptor; Ki=3.2 nM D3 receptor). |
| FB04808 | Adoprazine | 222551-17-9 | Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. |
| FB16500 | ABT-724 | 70006-24-5 | ABT-724 is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor. |
| FB16501 | ABT-724 3HCl | 587870-77-7 | ABT-724 3HCl is a potent and highly selective dopamine D4 receptor agonist with EC50s of 12.4 nM, 14.3 nM and 23.2 nM for human dopamine D4 receptor, rat D4 receptor and ferret D4 receptor. |
| FB15530 | A-381393 | 726174-00-1 | A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM)[1]. |
| FB08643 | (+)-PD 128907 HCl | 300576-59-4 | (+)-PD 128,907 HCl is an agonist of D3 dopamine receptor with Ki of 2.3 nM. |
| FB11940 | (+)-Dihydrexidine HCl | 158704-02-0 | (+)-Dihydrexidine HCl is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM. |
| FB16895 | (+)-AJ 76 HCl | 85378-82-1 | (+)-AJ 76 hydrochloride is an antagonist of dopamine receptor with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3, D4, hD2S, hD2L and rD2 receptors respectively). |