AMPK

AMPK

货号 产品名 CAS号 信息
FB06261 ZLN024 723249-01-2 ZLN024 is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM.
FB10277 ZLN024 HCl 1883548-91-1 ZLN024 HCl is an AMPK allosteric activator and activates α1β1γ1 and α2β1γ1 by around 2–2.5 fold with an EC50 of about 1–2 μM.
FB02701 YLF-466D 1273323-67-3 YLF-466D is an allosteric AMPK activator.
FB02364 WZ4003 1214265-58-3 WZ4003 is a potent and selective NUAK1/2 inhibitor with IC50 values of 20 and 100 nM, respectively.
FB10939 Thalidezine 18251-36-0 Thalidezine is an activiator of AMP-activated protein kinase (AMPK).
FB12627 PT 1 331002-70-1 PT 1 is a AMP-activated protein kinase (AMPK) activator.
FB06499 Phillyrin 487-41-2 Phillyrin is a naturally occuring AMPK activity enhancer, isolated and purified from the fruits of Forsythia suspensa.
FB08173 Phenformin HCl 834-28-6 Phenformin HCl is an AMPK activator which can increase the phosphorylation and activation of AMPKalpha1 and AMPKalpha2.
FB09957 PF-06409577 1467057-23-3 PF-06409577 is a potent and selective allosteric activator of AMPK with EC50 value of 7 nM for AMPKα1β1γ1, but >40000 nM for AMPKα1β2γ1.
FB16048 O-304   1261289-04-6 O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a drug to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].
FB11538 ex229 1219739-36-2 Novel AMPK activator, increasing AMPK activity of both AMPKgamma1- and AMPKgamma3-containing complexes in mouse skeletal muscle
FB01995 Mogroside IIIE 88901-37-5 Mogroside IIIE a naturally occuring cucurbitane glycoside which can attenuate gestational diabetes mellitus through activating of AMPK signaling pathway in mice.
FB10840 MK-8722 1394371-71-1 MK-8722 is a potent, direct, allosteric activator of all twelve mammalian AMPK complexes.
FB03036 Metformin HCl   1115-70-4 Metformin HCl, a widely used anti-diabetic drug has potential efficacy as an anti-cancer drug, decreasing hyperglycemia in hepatocytes primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
FB10205 GSK621 1346607-05-3 In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation.
FB17544 IM156 1422365-93-2 IM156 is a metformin derivative which has been reported to ameliorate various types of fibrosis and inhibit in vitro and in vivo tumors by inducing AMPK activation more potently than metformin. IM156 treatment impaired the function of virus-specific memory CD8+ T cells, indicating that excessive AMPK activation weakens memory T cell differentiation, thereby suppressing recall immune responses. IM156 activated AMPK in a dose-dependent manner, and produced shortening of the circadian period and enhanced degradation of the clock genes PER2 and CRY1.
FB09452 HTH-01-015 1613724-42-7 HTH-01-015 is a selective NUAK1 inhibitor, but not NUAK2, with IC50 of 100 nM, suppressing NUAK1-mediated MYPT1 phosphorylation.
FB00447 ETC-1002 738606-46-7 ETC-1002 is an AMPK activator and increase the level of AMPK phosphorylation.
FB04784 Dorsomorphin 866405-64-3 Dorsomorphin is a selective AMPK inhibitor with Ki value of 109 nM.
FB08616 Dorsomorphin 2HCl 1219168-18-9 Dorsomorphin 2HCl is a selective AMPK inhibitor with Ki value of 109 nM.
FB18230 COH-SR4   73439-19-7 COH-SR4 is an AMPK activator with anticancer properties. It significantly inhibited adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. It significantly reduced intracellular lipid accumulation and downregulated the expression of key adipogenesis-related transcription factors and lipogenic proteins in differentiating adipocytes.
FB09404 Chitosan oligosaccharide COS 148411-57-8 Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
FB17192 ASP4132 Besylate 1640294-30-9 ASP4132 is a new type of AMPK activator with EC50 value of 18nM. It showed attractive selective growth inhibition against human cancer cells.
FB02390 Ampkinone 1233082-79-5 Ampkinone is a small molecule activator of AMPK and stimulates functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 4.3 μM, enhancing glucose uptake by 3.2-fold.
FB12640 RSVA 405 140405-36-3 AMPK activator; also STAT3 inhibitor
FB18007 Amarogentin 21018-84-8 Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.
FB06244 AICAR Phosphate 681006-28-0 AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
FB10607 AICAR 2627-69-2 AICAR is an allosteric AMPK activator.
FB12844 Adenosine 5'-monophosphate, disodium salt 4578-31-8 Adenosine 5'-monophosphate disodium salt is an activator of AMPK and can be used as a substrate of AMP-thymidine kinase, AMP deaminase and 5′-nucleotidase.
FB05361 A-769662 844499-71-4 A-769662 is a reverible and allosteric activator of AMPK through inhibiting dephosphorylation of AMPK on Thr-172.
FB00764 1,8-Dihydroxyanthraquinone 117-10-2 1,8-Dihydroxyanthraquinone is a synthetic anthraquinone derivative, currently used as an antioxidant in synthetic lubricants, in the synthesis of antitumor agents, as a fungicide and as an intermediate for making dyes.
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