PKC
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB05533 | Zoledronic Acid Monohydrate | 165800-06-6 | Zoledronic acid is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines. |
| FB15285 | VTX-27 | 1321924-70-2 | VTX-27 is an inhibitor of protein kinase C θ (PKC θ) and PKC δ with Kis of 0.08 nM and 16 nM, respectively. |
| FB15373 | UCN-01 | 112953-11-4 | UCN-01 is a selective inhibitor of protein kinase C. |
| FB09530 | Staurosporine | 62996-74-1 | Staurosporine is a prototypical potent ATP-competitive multikinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| FB01111 | Sotrastaurin | 425637-18-9 | Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM and inactive to PKCζ. |
| FB12634 | Ro 32-0432 | 151342-35-7 | Ro 32-0432 is a selective and orally active inhibitor of protein kinase C prevents T-cell activation. It displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Ro 32-0432 is orally available and prevents T cell chronic inflammation in vivo. ). |
| FB09074 | Ro 31-8220 Mesylate | 138489-18-6 | Ro 31-8220 mesylate is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively. |
| FB02674 | Ro 31-8220 | 125314-64-9 | Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively. |
| FB12617 | Prostratin | 60857-08-1 | Prostratin is a PKC and NF-κB activator. |
| FB12664 | Ro 32-0432 HCl | 1781828-85-0 | Potent, orally active PKC inhibitor |
| FB16391 | Bryostatin 3 | 143370-84-7 | Potent protein kinase C activator |
| FB16837 | PKCβ Inhibitor | 257879-35-9 | PKCβ Inhibitor is a potent, reversible and ATP-competitive PKCβ inhibitor with IC50 values of 5nM and 21nM for PKCβII and βI, respectively. |
| FB08613 | PKC412 | 120685-11-2 | PKC412 is a broad spectrum protein kinase inhibitor and inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. |
| FB18208 | PKC-iota inhibitor 1 | 2328094-11-5 | PKC-iota inhibitor 1 PKC-ι ℩ inhibitor with IC50 value of 0.34μM. |
| FB01954 | PKC-IN-1 | 1046787-18-1 | PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 14.9 nM. |
| FB12619 | PKC β Pseudosubstrate | 172308-76-8 | PKC β Pseudosubstrate is a selective cell-permeable peptide inhibitor of protein kinase C with IC50 ~ 0.5 μM. |
| FB08250 | Phorbol 12-Myristate 13-Acetate | 16561-29-8 | Phorbol 12-myristate 13-acetate is a PKC-activating phorbol ester, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. |
| FB01284 | Phellopterin | 2543-94-4 | Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium. |
| FB06287 | NSC 305787 | 785718-37-8 | NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin. |
| FB06182 | NSC 305787 HCl | 53868-26-1 | NSC305787 HCl is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin. |
| FB06541 | Myricitrin | 17912-87-7 | Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, which exerts antinociceptive effects. |
| FB00623 | LY333531 HCl | 169939-93-9 | LY333531 is a β-specific protein kinase C inhibitor. It competitively and reversibly inhibits PKCβ1 and PKCβ2 with IC50 values of 4.7 and 5.9 nM respectively. |
| FB11295 | LXS196 | 1874276-76-2 | LXS196 is a potent and orally active protein kinase C (PKC) inhibitor used for the treatment of uveal melanoma. |
| FB11770 | KAI-9803 | 949100-39-4 | KAI-9803 is a potent and selective δ protein kinase C (δ PKC) inhibitor. |
| FB05054 | Isojacareubin | 50597-93-8 | Isojacareubin, a natural product isolated and purified from the roots of Garcinia fusca Pierre., is a potent inhibitor of protein kinase C (PKC), suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo, thus, it as a promising lead compound for the development of antihepatoma agents, and displays potent activity against H. |
| FB08904 | Ingenol Mebutate | 75567-37-2 | Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. |
| FB00124 | Go6983 | 133053-19-7 | Go6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ and PKCδ with IC50 of 7 nM, 7 nM, 6 nM and 10 nM, respectively and less potent to PKCζ and inactive to PKCμ. |
| FB01747 | Go6976 | 136194-77-9 | Gö6976 is a pan inhibitor of Ca2+-dependent PKC isozymes, PKCα and PKCβ1, with IC50 values of 2.3nM and 6.2nM, respectively, but has no effect on Ca2+-independent PKC isozymes PKCδ, ε and ζ. |
| FB08457 | Bisindolylmaleimide I | 133052-90-1 | GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. |
| FB12514 | FR 236924 | 28399-31-7 | FR 236924 is a selective PKCε activator. |
| FB06684 | Enzastaurin | 170364-57-5 | Enzastaurin is a potent PKCβ selective inhibitor with IC50 of 6 nM, 6- to 20-fold selectivity against PKCα, PKCγ and PKCε. |
| FB07824 | Decursinol angelate | 130848-06-5 | Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. |
| FB17245 | D-Sphingosine | 123-78-4 | D-Sphingosine inhibits protein kinase C. |
| FB06099 | Cycloheterophyllin | 36545-53-6 | Cycloheterophyllin, a natural product isolated and purified from the herbs of Artocarpus heterophyllus, exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA). |
| FB09400 | Chelerythrine | 34316-15-9 | Chelerythrine, a natural product isolated and purified from the herbs of Chelidonium majus with potent antimanic, antiproliferatvie and antitumor effect, can inhibit telomerase activity, and is a well-known protein kinase C inhibitor. |
| FB09399 | Chelerythrine Chloride | 3895-92-9 | Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) and competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. |
| FB03964 | CGP-60474 | 164658-13-3 | CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serine/threonine and tyrosine kinases and show competitive kinetics relative to ATP. |
| FB12578 | Calphostin C | 121263-19-2 | Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain with IC50 of 50 nM. |
| FB13026 | C-1 HCl | 141543-63-7 | C-1 HCl is a Protein kinase C and cyclic nucleotide dependent protein kinase inhibitor. |
| FB08843 | Bryostatin 1 | 83314-01-6 | Bryostatin 1 is a Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). |
| FB15700 | Bisindolylmaleimide X HCl | 145317-11-9 | Bisindolylmaleimide xHCl is a potent protein kinase C (PKC) inhibitor. |
| FB16535 | Bisindolylmaleimide IV | 119139-23-0 | Bisindolylmaleimide IV is an inhibitor of protein kinase C. |
| FB12188 | Bisindolylmaleimide II | 137592-45-1 | Bisindolylmaleimide II is a potent, ATP-competitive protein kinase C (PKC) inhibitor with IC50 of 0.01 μM, and also a potent nAChR antagonist. |
| FB02993 | Acteoside | 61276-17-3 | Acteoside, is a natural product isolated and purified from the herbs of Cistanche deserticola Y.C. Ma with known antioxidant activity. It is a protein kinase C inhibitor (IC50 =25 μM). |
| FB05400 | 20-Deoxyingenol 3-Angelate | 75567-38-3 | 20-Deoxyingenol 3-angelate, a natural product isolated and purified from the aerial parts of Euphorbia peplus L., can induce significant platelet aggregation accompanied by induction of phosphorylation of PKC substrates in platelets, it is a protein kinase C (PKC) activator, and is known as promoters of tumors of mouse skin. |
| FB07323 | (-)-Indolactam V | 90365-57-4 | (-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. |