CGRP Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB11377 | Ubrogepant | 1374248-77-7 | Ubrogepant is an oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine. |
| FB17228 | SB-268262 | 217438-17-0 | SB-268262 is a selective non-peptide CGRP antagonist with IC50 value of 0.83nM for inhibition of CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes. |
| FB15716 | Rat CGRP-(8-37) TFA salt | N/A | Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. |
| FB04071 | Olcegepant | 204697-65-4 | Olcegepant is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor (IC50= 0.03 nM). |
| FB03064 | MK-3207 | 957118-49-9 | MK-3207 is a potent and orally bioavailable CGRP receptor antagonist (IC50= 0.12 nM; Ki value= 0.024 nM), showing highly selective versus human AM1, AM2, CTR, and AMY3. |
| FB03063 | MK-3207 HCl | 957116-20-0 | MK-3207 HCl is a potent CGRP receptor antagonist with IC50 and Kiof 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3 |
| FB09441 | Telcagepant | 781649-09-0 | MK-0974 is a highly potent, selective, and orally bioavailable CGRP receptor antagonist with Ki values of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors respectively, displaying > 1500-fold lower affinity for the canine and rat receptors. |
| FB15717 | HCGRP-(8-37) TFA salt | N/A | HCGRP-(8-37) |
| FB11981 | CGRP Antagonist 1 | 1123757-49-2 | CGRP antagonist 1 is a highly potent CGRP receptor antagonist with a Ki and IC50 of 35 and 57 nM, respectively. |
| FB02708 | BMS-927711 | 1289023-67-1 | BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM. |