PGE synthesis (prostaglandin E synthase, PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB01173 | Zomepirac Sodium | 64092-48-4 | Zomepirac sodium is a pyrrole-acetic acid structurally related to tolmetin sodium and a prostaglandin synthetase inhibitor. |
| FB09639 | Suprofen | 40828-46-4 | Suprofen is a COX1/2 inhibitor and a non-steroidal anti-inflammatory drug (NSAID). |
| FB07588 | Pranoprofen | 52549-17-4 | Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology. |
| FB06904 | MF63 | 892549-43-8 | MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. |
| FB11636 | KW-8232 free base | 170365-25-0 | KW-8232 free base is an anti-osteoporotic agent, and can reduces the biosynthesis of PGE2. |
| FB02396 | hPGDS-IN-1 | 1234708-04-3 | hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay. |
| FB07029 | HPGDS Inhibitor 1 | 1033836-12-2 | HPGDS inhibitor 1 is a selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM. |
| FB15642 | GSK-2894631A | 2101626-26-8 | GSK-2894631A is a highly potent and selective HPGDS inhibitor with IC50 value of 9.9nM. |
| FB10477 | Flurbiprofen | 5104-49-4 | Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. |
| FB08485 | Bismuth Subsalicylate | 14882-18-9 | Bismuth subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2. |
| FB18264 | AT-56 | 162640-98-4 | AT 56 is an orally active L-PGDS inhibitor with IC50 value of 95μM. It inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production. |