Sigma Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB09897 | Anavex 2-73 HCl | 195615-84-0 | σ1 agonist (IC50 = 860 nM); also displays affinity for muscarinic M1-M4 receptors (Ki values < 500 nM), but not for σ2 receptors. Exhibits neuroprotective effects, prevents tau hyperphosphorylation, and attenuates scopolamine- and (+)-MK 801-induced learning deficits in a mouse model of amyloid toxicity. |
| FB03828 | Siramesine | 147817-50-3 | Siramesine is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. |
| FB01710 | Siramesine HCl | 224177-60-0 | Siramesine HCl is an agonist of sigma-2 receptor which can trigger cell death and exhibit anticancer activity. |
| FB03966 | SA4503 | 165377-43-5 | SA4503 is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM. |
| FB09138 | SA4503 2HCl | 165377-44-6 | SA4503 2HCl is the 2HCl form of SA4503 which is an agonist of opioid sigma1 receptor (σ1R) with IC50 of 17.4 nM. |
| FB01539 | S1RA | 878141-96-9 | S1RA is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM). |
| FB02694 | S1RA HCl | 1265917-14-3 | S1RA HCl is a potent and selective sigma-1 receptor (σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM). |
| FB09002 | Remoxipride | 80125-14-0 | Remoxipride is an atypical antipsychotic which was previously used in Europe for the treatment of schizophrenia and acute mania but was withdrawn due to toxicity concerns (incidence of aplastic anemia in 1/10,000 patients). |
| FB04415 | Pridopidine | 346688-38-8 | Pridopidine exhibits high affinity towards sigma 1 receptor (S1R) (Ki = 70-80 nM) which can counteract the effects of excessive or insufficient dopaminergic transmission and it can used as a dopamine (DA) stabilizer. |
| FB06273 | PRE-084 HCl | 75136-54-8 | PRE-084 HCl is a high affinity, selective σ1 agonist, has an IC50 of 44 nM in the sigma receptor assay. |
| FB07691 | Noscapine | 128-62-1 | Noscapine is an orally administrable drug used worldwide for cough suppression, primarily mediated by its σ-receptor agonist activity, and possess anticancer activity. |
| FB15315 | Dimemorfan Phosphate | 36304-84-4 | Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive. |
| FB00050 | Dextromethorphan | 125-71-3 | Dextromethorphan is a drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses). |
| FB17282 | BD1063 | 150208-28-9 | BD1063 is a selective sigma receptor antagonist, with a Ki of 9 ± 1 nM for the sigma-1 receptor. |
| FB16050 | BD1063 dhydrochloride | 206996-13-6 | BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist. |
| FB10687 | BD-1047 Dihydrobromide | 138356-21-5 | BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia. |
| FB03297 | 4-IBP | 155798-08-6 | 4-IBP is selective σ1 agonist with Ki of 1.7 nM and 25.2 nM for σ2 receptor. |