Prostaglandin Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB03366 | Treprostinil Sodium | 289480-64-4 | Treprostinil sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. |
| FB00414 | Travoprost | 157283-68-6 | Travoprost is a synthetic prostaglandin F2α analog as a potent and selective FP prostaglandin receptor agonist, used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. |
| FB00640 | TG6-10-1 | 1415716-58-3 | TG6-10-1 is an antagonist of prostaglandin E2 receptor subtype EP2. |
| FB03967 | Terutroban | 165538-40-9 | Terutroban is a thromboxane/prostaglandin endoperoxide receptor antagonist. |
| FB17172 | TCS 2510 | 346673-06-1 | TCS 2510 is a highly selective agonist of EP4 receptor with EC50 of 2.5 nM and Ki of 1.2 nM. It does not bind at other prostaglandin receptors. |
| FB11868 | Taprenepag Isopropyl | 1005549-94-9 | Taprenepag isopropyl is a highly selective EP2 receptor agonist. |
| FB06274 | Taprenepag | 752187-80-7 | Taprenepag is an agonist of prostaglandin E2 receptor with EC50 of 2.8 nM with hypotensive activity. |
| FB01230 | Setipiprant | 866460-33-5 | Setipiprant is an orally available, selective CRTH2 antagonist. |
| FB17167 | SC 51089 | 146033-02-5 | SC-51089, also known as CID132748, is an antagonist of PGE2 and selective for the EP1 receptor subtype with antinociceptive activity. |
| FB17166 | SC 51322 | 146032-79-3 | SC 51322 is an antagonist of EP1 prostanoid receptor with Ki of 13.8 nM. |
| FB17175 | SC 19220 | 19395-87-0 | SC 19220 is a competitive antagonist of EP1 receptor. |
| FB15226 | Treprostinil | 81846-19-7 | Rumodolinl, a analog of prostacyclin, is an agonist of IP receptor that used clinically to treat pulmonary arterial hypertension. It is a vasodilator with antithrombotic and anti-inflammatory properties. |
| FB00940 | RO1138452 | 221529-58-4 | RO1138452 is a selective antagonist of prostacyclin (IP) receptor with pKi of 9.3 ± 0.1 in human platelets. |
| FB08650 | Prostaglandin E2 | 363-24-6 | Prostaglandin E2 is a natural prostaglandin and acts as a vasodilator by activating the prostaglandin E2 receptor. |
| FB08649 | Prostaglandin D2 | 41598-07-6 | Prostaglandin D2 is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. |
| FB09451 | PF-04418948 | 1078166-57-0 | PF-04418948 is an antagonist of prostaglandin EP2 receptor with IC50 of 16 nM. |
| FB04941 | ONO-AE3-208 | 402473-54-5 | ONO-AE3-208 is an antagonist of EP4 with Ki of 1.3 nM and exhibits suppression the invasion and metastasis of prostate cancer cells. |
| FB17169 | ONO 8130 | 459841-96-4 | ONO 8130 is an antagonist of EP1 receptor. |
| FB05163 | OC000459 | 851723-84-7 | OC000459 is a potent and selective D prostanoid receptor 2 (DP2) antagonist with IC50 of 13 nM. |
| FB12060 | OBE022 | 2005486-31-5 | OBE022 is an oral and selective prostaglandin F2α (PGF2α) receptor antagonist, with Kis of 1 nM, 26 nM for human and rat FP receptors, respectively. |
| FB06142 | NS-304 | 475086-01-2 | NS-304 is an agonist of prostacyclin IP1 receptor with Ki of 260 nM. It is used for the treatment of pulmonary arterial hypertension. |
| FB08518 | MRE-269 | 475085-57-5 | MRE-269 can act as an agonist of IP receptor and it is an active metabolite of selexipag. |
| FB01917 | MK-2894 Sodium | 1006036-88-9 | MK-2894 sodium is a highly potent and selective second generation EP4 antagonist. |
| FB01916 | MK-2894 | 1006036-87-8 | MK-2894 is a highly potent and selective second generation EP4 antagonist. |
| FB10743 | Misoprostol | 59122-46-2 | Misoprostol is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion. |
| FB00704 | MF498 | 915191-42-3 | MF498 is a selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7 nM. |
| FB03427 | Limaprost | 74397-12-9 | Limaprost is a PGE1 analog and potent platelet adhesion inhibitor. |
| FB06196 | Laropiprant | 571170-77-9 | Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM). |
| FB10837 | L-798,106 | 244101-02-8 | L-798106 is a potent and highly selective prostanoid EP3 receptor antagonist (Ki values are 0.3, 916, > 5000 and > 5000 nM at EP3, EP4, EP1 and EP2, respectively), and it can attenuate sulprostone-induced inhibition of EFS-evoked twitch and contractile responses in vivo. |
| FB17174 | L-161,982 | 147776-06-5 | L-161,982 is a potent EP4 receptor antagonist with Ki value of 0.024 μM. |
| FB02847 | Ifetroban | 143443-90-7 | Ifetroban is a long-acting thromboxane A2 receptor antagonist, with antiplatelet activity. |
| FB04956 | GW627368 | 439288-66-1 | GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor (Ki= 100 nM) with additional human TP receptor affinity (Ki= 150 nM). |
| FB04947 | Grapiprant | 415903-37-6 | Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). |
| FB04813 | Evatanepag | 223488-57-1 | Evatanepag is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation with EC50 of 0.3 nM. |
| FB00512 | Esuberaprost Sodium | 88475-69-8 | Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH). |
| FB10903 | Esuberaprost | 94132-88-4 | Esuberaprost is a potential substance for treating pulmonary arterial hypertension (PAH). |
| FB17179 | ER 819762 | 1155773-15-1 | ER 819762 is an antagonist of EP4 receptor with IC50 of 59 nM. |
| FB08652 | Dinoprost Tromethamine | 38562-01-5 | Dinoprost tromethamine is a natural prostaglandin used as an abortifacient. |
| FB08651 | Dinoprost | 551-11-1 | Dinoprost is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. |
| FB17173 | DG 041 | 861238-35-9 | DG-041 is a potent and selective antagonist of prostanoid EP3 receptor with IC50 of 4.6 nM. |
| FB07824 | Decursinol angelate | 130848-06-5 | Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. |
| FB16666 | Cloprostenol Sodium Salt | 55028-72-3 | Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist. |
| FB17243 | (+)-Cloprostenol (sodium salt) | 62561-03-9 | Cloprostenol is a PGF2 α analogue, working as an FP receptor agonist. |
| FB02858 | CJ-42794 | 847728-01-2 | CJ-42794 is a selective prostaglandin E receptor subtype 4 (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3). |
| FB09174 | Carbacyclin | 69552-46-1 | Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation. |
| FB03128 | Bimatoprost | 155206-00-1 | Bimatoprost, a analog of prostaglandin, can control the progression of glaucoma and ocular hypertension. |
| FB17177 | BGC 20-1531 HCl | 1962928-26-2 | BGC 20-1531 hydrochloride is a selective antagonist of EP4 with Ki of 3 nM. |
| FB16562 | Asapiprant | 932372-01-5 | Asapiprant is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM. |
| FB05162 | Alprostadil | 745-65-3 | Alprostadil is an analog of prostaglandin which is prostaglandin E1 agonist with vasodilatory properties and can be used to treat erectile dysfunction. |
| FB01401 | AH 6809 | 33458-93-4 | AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors. |