Trk Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB11160 | TrkA Inhibitor C6t | 1377503-70-2 | TrkA inhibitor C6t is a potent and selective TrkA inhibitor (IC50=1.67 nM) showing activity in cellular proliferation and apoptosis assays and exhibiting antiangiogenic activity. |
| FB11161 | Trk Inhibitor C11 | 1614229-04-7 | Trk inhibitor C11 is an orally active pan-Trk inhibitor showing efficacy in both inflammatory and neropathic pain models. |
| FB17559 | Taletrectinib | 1505515-69-4 | Taletrectinib is a new-generation selective ROS1/Trk Receptor inhibitor with IC50 values of 0.207nM, 0.622nM, 2.28nM and 0.98nM for ROS1, Trk Receptor A, B and C, respectively. It induces dramatic growth inhibition of both wild type and G2032R mutant ROS1-rearranged cancers or NTRK-rearranged cancers in vitro and in vivo. |
| FB11158 | PF-06273340 | 1402438-74-7 | PF-06273340 is a potent, selective and orally bioavailable pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). It is peripherally restricted and exhibits efficacy in a rodent model of inflammatory pain. |
| FB13159 | Loxo-195 | 2097002-61-2 | LOXO-195 is a TRK kinase inhibitor (TKI) with IC50 values of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively. |
| FB02379 | LOXO-101 Sulfate | 1223405-08-0 | LOXO-101 sulfate blocks the ATP binding site of the TRK family of receptors with IC50 of 2 nM to 20 nM against TRKA, TRKB, and TRKC. |
| FB01584 | LOXO-101 | 1223403-58-4 | LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members. |
| FB12168 | LM22B-10 | 342777-54-2 | LM22B-10 is an agonist of TrkB and TrkC neurotrophin receptor. It can improve survival and increase neurite outgrowth in vitro. |
| FB08799 | LM22A-4 | 37988-18-4 | LM22A-4 is a specific agonist oftyrosine kinase receptor B. |
| FB04183 | GW441756 | 504433-23-2 | GW 441756 is an inhibitor of tropomyosin-related kinase A (TrkA) with IC50 of 2 nM. |
| FB08598 | GNF-5837 | 1033769-28-6 | GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). |
| FB11159 | GNF-8625 | 1196546-33-4 | GNE-8525 is a potent and selective pan-TRK inhibitor, demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily (bid) for 14 days in rats. |
| FB11796 | CE-245677 | 717899-97-3 | CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM. |
| FB00953 | AZ-23 | 915720-21-7 | AZ-23 is a potent, orally bioavailable Trk kinase inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively. |
| FB08025 | ANA-12 | 219766-25-3 | ANA-12 is antagonist of TrkB with Kd of 10 nM. |
| FB06814 | 7,8-Dihydroxyflavone | 38183-03-8 | 7,8-Dihydroxyflavone acts as an agonist of TrkB receptor with Kd of 320 nM with neuroprotective effect. |