ACC
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB11244 | Olumacostat Glasaretil | 1261491-89-7 | Olumacostat glasaretil is an acetyl-CoA carboxylase inhibitor, and inhibits acetyl-coenzyme A carboxylase, which is responsible for the first, rate-limiting step in de novo fatty acid synthesis. Olumacostat glasaretil has been used in the treatment of acne vulgaris. |
| FB11629 | ND-646 | 1434639-57-2 | ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. |
| FB11628 | ND-630 | 1434635-54-7 | ND-630 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits ACC1 and ACC2 activity (IC50s = 2.1 and 6.1 nM, respectively, for the human enzymes). |
| FB11359 | MK-4074 | 1039758-22-9 | MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM. |
| FB06204 | CP-640186 HCl | 591778-70-0 | CP-640186 HCl is a metabolic stability improved ACC inhibitor with IC50 values of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2,respectively. |