CAS:21256-18-8Oxaprozin

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Oxaprozin 奥沙普秦 Cat No. FB06797Cas No. 21256-18-8

Synonyms: WY 21743

Oxaprozin is a COX inhibitor with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, it's a NSAID used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4093 mL
- 17.0464 mL
- 34.0929 mL
- 5 mM
- 0.6819 mL
- 3.4093 mL
- 6.8186 mL
- 10 mM
- 0.3409 mL
- 1.7046 mL
- 3.4093 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

21256-18-8

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C18H15NO3

运输

蓝冰

分子量

293.32

别名

WY 21743

溶解度

DMSO	140.0 mg/mL (477.3 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin reversed in a dose-dependent manner immune complex-induced survival of monocytes, without affecting the apoptosis of resting cells. Other NSAIDs (Non-steroidal anti-inflammatory drugs) are ineffective. Oxaprozin-mediated inhibition of the Akt/IKK/NF-kappaB pathway contributes to its anti-inflammatory properties^[3]. Among different NSAIDs, only oxaprozin dose-dependently increased apoptosis of CD40L-treated monocytes. Oxaprozin pro-apoptotic activity was associated with the inhibition of CD40L-triggered Akt and NF-kappaB phosphorylation and the activation of caspase 3^[4].