MLK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB08077 | URMC-099 | 1229582-33-5 | URMC-099 is an orally bioavailable, brain penetrant inhibitor of Mixed Lineage Kinase 3 (MLK3) with IC50 of 14 nM. It inhibits LPS-induced TNFα release in microglial cells, HIV-1 Tat-induced release of cytokines in human monocytes, and up-regulation of phospho-JNK in Tat-injected brains of mice. |