p53
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
FB00963 | YH239-EE | 1364488-67-4 | YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent. |
FB01540 | Tenovin-3 | 1011301-27-1 | Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM. |
FB08800 | Tenovin 1 | 380315-80-0 | Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53. It protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. |
FB05133 | JNJ-26854165 | 881202-45-5 | Serdemetan acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, and inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. |
FB08566 | PRIMA-1 | 5608-24-2 | PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53. |
FB08442 | Plumbagin | 481-42-5 | Plumbagin is an anticancer agent, induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation and inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. |
FB16450 | PK11007 | 874146-69-7 | PK11007 is mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53. |
FB12169 | PK11000 | 38275-34-2 | PK11007 is a p53 targeting compond anti-tumor activities. |
FB08203 | Pifithrin-μ | 64984-31-2 | Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
FB06212 | Pifithrin-β | 60477-34-1 | Pifithrin-β is a potent p53 inhibitor with IC50 of 23 μM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1. |
FB08738 | Pifithrin-β Hydrobromide | 511296-88-1 | Pifithrin-β hydrobromide is a potent p53 inhibitor with IC50 of 23 μM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1. |
FB08476 | Pifithrin-α Hydrobromide | 63208-82-2 | Pifithrin-α hydrobromide is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. |
FB03060 | p53 and MDM2 Proteins-interaction-inhibitor Racemic | 939983-14-9 | p53 and MDM2 proteins-interaction-inhibitor racemate is an inhibitor of the interaction between p53 and MDM2 proteins. |
FB03822 | p53 and MDM2 Proteins-interaction-inhibitor Chiral | 939981-37-0 | p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins. |
FB10027 | p53 and MDM2 proteins-interaction-inhibitor 2HCl | 2070009-27-5 | p53 and MDM2 proteins-interaction-inhibitor 2HCl is an inhibitor of the interaction between p53 and MDM2 proteins. |
FB01611 | NSC 319726 | 71555-25-4 | NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM) and showing no inhibition for p53 wild-type cells. |
FB16453 | NSC 207895 | 58131-57-0 | NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator. |
FB08627 | MI-773 | 1303607-07-9 | MI-773 is an orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity. |
FB00638 | Kevetrin HCl | 66592-89-0 | Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity. |
FB01992 | DehydropachyMic acid | 77012-31-8 | Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity. |
FB11319 | CP-31398 2HCl | 1217195-61-3 | CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. |
FB12826 | COTI-2 | 1039455-84-9 | COTI-2 is an orally available thiosemicarbazone and mutant p53 activator with potential antineoplastic activity. |
FB01385 | APR-246 | 5291-32-7 | APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. |
FB12643 | RETRA HCl | 1173023-52-3 | Antitumor agent; suppresses mutant p53-bearing cancer cells |
FB02784 | AMG-232 | 1352066-68-2 | AMG-232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction ((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM). |