5-HT Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB12747 | WAY 208466 2HCl | 1207064-61-6 | WAY-208466 2HCl is a selective serotonin 5-HT6 receptor agonist. |
| FB00891 | Vilazodone | 163521-12-8 | Vilazodone is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
| FB12733 | Tropanserin | 85181-40-4 | Tropanserin is a selective 5-HT3 receptor antagonist. |
| FB17662 | Tianeptine | 66981-73-5 | Tianeptine is an atypical antidepressant drug. It decreases serotonin's activity and amount in serotonergic synapses of the central nervous system by increasing serotonin reuptake. |
| FB00173 | Tiamenidine | 31428-61-2 | Thioridazine is an antipsychotic drug, used in the treatment of schizophrenia and psychosis, shows D4 selectivity or serotonin antagonism. |
| FB12708 | ST 1936 Oxalate | 1782228-83-4 | ST1936 oxalate is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 oxalate also shows moderate affinity (Ki of 300 nM) for human α2 adrenergic receptor . |
| FB12702 | ST 1936 | 1210-81-7 | Selective, high affinity 5-HT6 agonist |
| FB12671 | SB 258719 HCl | 1217674-10-6 | Selective 5-HT7 antagonist |
| FB12672 | SGS 518 Oxalate | 445441-27-0 | Selective 5-HT6 antagonist |
| FB12742 | WAY 629 HCl | 57756-44-2 | Selective 5-HT2C agonist |
| FB12670 | SDZ SER 082 Fumarate | 1417343-80-6 | Selective 5-HT2B/2C antagonist |
| FB12703 | Tandospirone HCl | 99095-10-0 | Selective 5-HT1A partial agonist |
| FB12395 | Zimelidine 2HCl | 60525-15-7 | Selective 5-HT uptake inhibitor |
| FB12659 | SB 215505 | 162100-15-4 | SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats. |
| FB12412 | SB 399885 HCl | 402713-81-9 | SB-399885 hydrochloride is a 5-HT6 receptor antagonist. |
| FB12662 | SB 699551 | 864741-95-7 | SB 699551 is a selective 5-ht5a receptor antagonist (pKi values are 8.3, < 6.0, < 6.0, < 6.0, < 5.5 and < 5.5 for 5-ht5a, 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors respectively). |
| FB12658 | SB 243213 HCl | 200940-23-4 | SB 243213 hydrochloride is a selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 hydrochloride has improved anxiolytic profile[1]. |
| FB12668 | SB 243213 2HCl | 1780372-25-9 | SB 243213 dihydrochloride is an orally active, selective and high-affinity 5-hydroxytryptamine (5-HT)2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 dihydrochloride has improved anxiolytic profile and has the potential for schizophrenia and motor disorders . |
| FB12418 | SB 221284 | 196965-14-7 | SB 221284 is potent, selective 5-HT2C/2B receptor antagonist. SB 221284 are pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors respectively. |
| FB08054 | Promethazine HCl | 58-33-3 | Promethazine HCl is the effective antagonist of the H1 receptor and moderate antagonist of mACh receptor. |
| FB12679 | SB 258585 HCl | 1216468-02-8 | Potent, selective 5-HT6 antagonist |
| FB12689 | SR 57227 HCl | 77145-61-0 | Potent and selective 5-HT3 agonist |
| FB12758 | WAY 161503 HCl | 276695-22-8 | Potent and selective 5-HT2C agonist |
| FB17807 | Phenylbiguanide | 102-02-3 | Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM. |
| FB04854 | Pardoprunox HCl | 269718-83-4 | Pardoprunox HCl is a partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A receptor (pKi = 8.5) full agonist. |
| FB17995 | Paliperidone palmitate | 199739-10-1 | Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester prodrug of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia. |
| FB17547 | p-MPPI HCl | 220643-77-6 | p-MPPI is a novel 5-HT Receptor 1A receptor antagonist. It produced a significant and dose-related anxiolytic profile in male mice. |
| FB17766 | Org-12962 | 132834-56-1 | Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety. |
| FB12487 | NPS ALX Compound 4a 2HCl | 1781934-44-8 | NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM . |
| FB17231 | LY344864 racemate | 186543-64-6 | LY344864 racemate is the racemate form of LY344864. LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor. |
| FB13122 | Lecozotan | 434283-16-6 | Lecozotan is a potent and selective 5-HT(1A) receptor antagonist. It significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. It produced a significant improvement in task performance efficiency at an optimal dose (1 mg/kg p.o.) in aged rhesus monkeys. |
| FB08141 | Perospirone HCl 3H2O | 129273-38-7 | In CHO cells expressing human 5-HT1A receptors, perospirone shows a high affinity (Ki = 0.72 nM), and exhibits partial agonistic efficacy. |
| FB12677 | S 14506 HCl | 286369-38-8 | Highly potent 5-HT1A agonist; displays unique binding mechanism |
| FB12739 | WAY 181187 Oxalate | 1883548-85-3 | High affinity and selective 5-HT6 agonist |
| FB05102 | Galanolactone | 115753-79-2 | Galanolactone, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe with cytotoxic activity, has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes, and inhibits nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. |
| FB16019 | F-15599 | 635323-95-4 | F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist with Ki value of 3.4nM. |
| FB16872 | Elopiprazole | 115464-77-2 | Elopiprazole is an antipsychotic drug of the phenylpiperazine class. |
| FB17833 | Dehydroaripiprazole | 129722-25-4 | Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole. |
| FB07931 | Colfosceril Palmitate | 63-89-8 | Colfosceril palmitate is a drug used as a pulmonary surfactant. It is also a key conponent of LNP as an effective delivery vehicle of mRNA. |
| FB15293 | AVN492 | 1220646-23-0 | AVN492 is a selective antagonist of 5-HT6R with Ki of 91 pM. |
| FB16271 | 5-Methoxytryptamine | 608-07-1 | 5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. |
| FB12443 | RS 67506 HCl | 168986-61-6 | 5-HT4 partial agonist |
| FB12394 | RS 23597-190 HCl | 149719-06-2 | 5-HT4 antagonist |
| FB12636 | RS 39604 HCl | 167710-87-4 | 5-HT4 antagonist |
| FB12632 | RS 56812 HCl | 143339-12-2 | 5-HT3 partial agonist |
| FB12663 | SB 200646 HCl | 143797-62-0 | 5-HT2C/2B antagonist |
| FB12673 | S 32212 HCl | 847871-78-7 | 5-HT2C inverse agonist; α2-adrenoceptor antagonist |
| FB12783 | α-Methyl-5-hydroxytryptamine Maleate | 97469-12-0 | 5-HT2B agonist |
| FB12646 | RU 24969 Hemisuccinate | 66611-27-6 | 5-HT1A and 5-HT1B agonist |
| FB17954 | 2-Methyl-5-HT | 78263-90-8 | 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects. |