CAS:74103-07-4Ketorolac Tromethamine

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Synonyms: Ketorolac Tris Salt

Ketorolac is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

74103-07-4

储存条件

分子式

C19H24N2O6

运输

蓝冰

分子量

376.40

别名

Ketorolac Tris Salt

溶解度

DMSO	120.0 mg/mL (318.8 mM)
Water	105.0 mg/mL (279.0 mM)

动物实验配方

生物活性

描述Ketorolac Tromethamine (ketorolac) is a non-steroidal anti-inflammatory agent, acting as a non-selective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS (lipopolysaccharide) endotoxin-induced increases in FITC-dextran (fluorescein isothiocyanate) in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits. Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. It reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats^[3]. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats^[4]. Ketorolac tromethamine 0.4% has equivalent efficacy to ketorolac tromethamine 0.5% in reducing postsurgical inflammation and controlling pain. Ketorolac tromethamine 0.4% effectively treats cystoid macular oedema, inhibits miosis and may prevent cystoid macular oedema when used both pre- and postoperatively, as well as reducing pain and ocular inflammation^[5].