AChE
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00803 | Valethamate Bromide | 90-22-2 | Valethamate bromide is generally used as an anticholinergic agent. |
| FB09647 | Tacrine HCl | 1684-40-8 | Tacrine HCl is a parasympathomimetic reversible cholinesterase inhibitor. |
| FB06628 | Skimmianin | 83-95-4 | Skimmianin, a natural product isolated and purified from the herbs of Skimmia japonica, is an inhibitor against the Leishmania APRT enzyme and a strong acetylcholinesterase (AChE) inhibitor, and has a selective inhibitory effect on the 5-hydroxytryptamine-induced vasopressor responses of rats. |
| FB09071 | Rivastigmine | 123441-03-2 | Rivastigmine is a acetylcholinesterase inhibitor with IC50 value of 5.5 μM for cholinesterase, used for the treatment of mild to moderate Alzheimer's disease and Parkinson's disease. |
| FB08871 | Pyridostigmine Bromide | 101-26-8 | Pyridostigmine Bromide is a reversible cholinesterase inhibitor to treat myasthenia gravis. |
| FB04471 | Pseudopalmatine | 19716-66-6 | Pseudocolumbamine is a natural product isolated and purified from the herbs of Tinospora sinensis with antiplasmodial activity ,it's also a AChE inhibitor with IC50 of 1.8 μM. |
| FB03872 | Pralidoxime Chloride | 51-15-0 | Pralidoxime chloride is an AChE reactivator, used as an antidote to organophosphate pesticides and chemicals. |
| FB11942 | (+)-Phenserine | 116839-68-0 | Posiphen is a selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM. |
| FB15490 | PItofenone HCl | 1248-42-6 | Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively. |
| FB08436 | Pitofenone | 54063-52-4 | Pitofenone an AChE inhibitor with Ki values of 36 and 45 μM for bovine erythrocyte and electric eel enzyme, which shows anti-spasmodic activity in combination with Fenpiverinium and Diclofenac. |
| FB02775 | Pipenzolate | 13473-38-6 | Pipenzolate is a muscarinic receptor antagonist, preventing acetyl choline from binding to the receptors. |
| FB08370 | Picfeltarraenin IA | 97230-47-2 | Picfeltarraenin IA, a natural product isolated and purified from the herbs of Picria felterrae Lour., is a stronger AChE inhibitor than the known AChE inhibitor Tacrine, a potential PI3K and epidermal growth factor receptor (EGFR ) inhibitor with anti-inflammatory activity, and acts as an inhibitor on both the classical and alternative pathways of the complement system. |
| FB08359 | Physostigmine | 57-47-6 | Physostigmine is also reported to form a slowly degrading carbamylated enzyme complex with AChE (acetylcholinesterase). |
| FB04325 | N-p-trans-Coumaroyltyramine | 36417-86-4 | N-p-trans-Coumaroyltyramine, a natural product isolated and purified from the herbs of Exochorda racemosa, is an α-glucosidase inhibitor(Ki = 840 nM in yeast) and an AChE inhibitor (IC50 = 34.5 mg/mL/122 mM), exhibits potent inhibition of cell proliferation, platelet aggregation, and shows antioxidant activity. |
| FB05299 | N-Methylcalycinine | 86537-66-8 | N-Methylcalycinine, a natural product isolated and purified from the root of Stephania epigaea, exhibits potent AChE inhibitory activity. |
| FB00449 | Metrifonate | 52-68-6 | Metrifonate is an irreversible organophosphate acetylcholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. |
| FB03854 | Malathion | 121-75-5 | Malathion is an organophosphate parasympathomimetic which binds irreversibly to cholinesterase, is an insecticide of relatively low human toxicity. |
| FB05901 | Lucidadiol | 252351-95-4 | Lucidadiol is a natural product isolated and purified from the herbs of fungus Ganoderma pfeifferi with inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM, butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, and antiviral activity against influenza virus type A and HSV type 1. |
| FB02430 | Itopride HCl | 122892-31-3 | Itopride HCl is a D2 antagonist and an AChE inhibitor with an IC50 value of 2.04±0.27 μM. It is a prokinetic benzamide derivative unlike domperidone. |
| FB10609 | Huperzine A | 102518-79-6 | Huperzine A is a naturally occurring sesquiterpene alkaloid AChE inhibitor. |
| FB02417 | Hederacoside C | 14216-03-6 | Hederacoside C is a naturally occuring saponin found in K. pictus with anti-inflammatory activity. It inhibited AChE with IC50 value of 31.3 μM. |
| FB04371 | Garcinone C | 76996-27-5 | Garcinone C, a natural product isolated and purified from the fruits of Garcinia mangostana, is the most potent inhibitor of AChE, the most active compound against both of pathogenic (MIC =100 μg/mL) and non-pathogenic leptospira (MIC = 200 μg/mL), and exhibits either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro. |
| FB01102 | Galanthamine | 357-70-0 | Galanthamine is a long-acting, centrally active acetylcholinesterase (AChE) inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. |
| FB10614 | Galanthamine Hydrobromide | 1953-04-4 | Galanthamine hydrobromide is a natural occuring AchE inhibitor with IC50 value of 410nM and allosteric potentiator at neuronal nAchRs, used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments. |
| FB06683 | Galanthaminone | 510-77-0 | Galantamine is a competitive and reversible cholinesterase (AChE) inhibitor and is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. |
| FB01256 | Edrophonium Chloride | 116-38-1 | Edrophonium chloride is a competitive AchE inhibitor which can prevent breakdown of the neurotransmitter acetylcholine. |
| FB00310 | Donepezil | 120014-06-4 | Donepezil is a centrally acting reversible AchE inhibitor with IC50 of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively, a medication used to treat Alzheimer's disease. |
| FB00617 | Dimetacrine | 4757-55-5 | Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression. |
| FB15318 | Demecarium Bromide | 56-94-0 | Demecarium Bromide (BC-48) is a potent cholinesterase inhibitor, with an apparent affinity (Kiapp) of 0.15 μM[1]. Demecarium Bromide (BC-48) is used as a glaucoma agent[2]. |
| FB17755 | Coumaran | 496-16-2 | Coumaran (2,3-Dihydrobenzofuran) is an acetylcholinesterase (AChE) inhibitor isolated from leaves of L. camara. Coumaran can be used as a biopesticide. |
| FB09783 | Corydaline | 518-69-4 | Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo. |
| FB08666 | Bretylium Tosylate | 61-75-6 | Bretylium tosylate is an antiarrhythmic agent. |
| FB04321 | beta-Amyrone | 638-97-1 | beta-Amyrone, a natural product isolated and purified from the leaves of Cyclocarya paliums with snakevenom inactivating action, exhibits moderate anti-acetylcholinesterase (AChE) activity. |
| FB16143 | Azinphos-methyl | 86-50-0 | Azinphos-methyl is an AChE inhibitor used as an insecticide. |
| FB04742 | alpha-Viniferin | 62218-13-7 | alpha-Viniferin, a natural product isolated and purified from the herb of Carex humilis Leyss., a specific, reversible and noncompetitive AChE inhibitor (IC50 = 2.0 mM), exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 mM, and has anti-inflammatory activity, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages. |
| FB07448 | Aldicarb Sulfone | 1646-88-4 | Aldicarb sulfone, a carbamate insecticide, is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse. |
| FB07447 | Aldicarb | 116-06-3 | Aldicarb is a carbamate insecticide and a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse. |
| FB07935 | Acotiamide | 185106-16-5 | Acotiamide is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. It acts as an acetylcholinesterase inhibitor. |
| FB12861 | Acotiamide HCl | 185104-11-4 | Acotiamide HCl is the 2HCl form of acotiamide which is an inhibitor of AChE. It also acts as a prokinetic drug through acetylcholinesterase inhibition and muscarinic receptor antagonism that is used for the treatment of functional dyspepsia. |
| FB08417 | Acotiamide HCl 3H2O | 773092-05-0 | Acotiamide HCl 3H2O is AchE inhibitor which can increased Ach concentrations and lead to an improvement of gastric emptying and gastrointestinal motility and eventually to a reduction of dyspepsia symptoms. |
| FB09968 | Isochlorogenic Acid B | 14534-61-3 | 3,4-Dicaffeoylquinic Acid is a polyphenol with diverse biological activities, it inhibits acetylcholinesterase (ACE) and α-glucosidase in a concentration-dependent manner, shows cytotoxic to NCI-H23 lung adenocarcinoma cells, as well as increases tumor necrosis factor-related apoptosis inducing ligand (TRAIL) mRNA, reduces influenza H1N1 hemagglutinin (HA) mRNA and increases survival in a mouse model of influenza A infection. |
| FB16332 | 1-Naphthyl acetate | 830-81-9 | 1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. |
| FB10597 | (±)-Huperzine A | 120786-18-7 | (±)-Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbs of Lycopodium serratum, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). |
| FB09784 | (+)-Corynoline | 18797-79-0 | (+)-Corynoline is an AChE inhibitor isolated from Corydalis incisa. |