ROR
货号 | 产品名 | CAS号 | 信息 |
---|---|---|---|
FB12741 | XY 018 | 1873358-87-2 | XY 018 is a RORγ antagonist that suppresses androgen receptor expression in prostate cancer cell lines and inhibits growth of tumors in androgen receptor-positive xenograft models. |
FB12100 | TMP778 | 1422171-08-1 | TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay. |
FB04868 | SR-3335 | 293753-05-6 | SR3335 can selectively bind to RORα and competitively inhibit the binding of 25-hydroxycholesterol to the ligand binding domain with Ki of 220 nM. |
FB12694 | SR 2211 | 1359164-11-6 | SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM. |
FB02751 | SR-1001 | 1335106-03-0 | SR1001 is a selective RORα and RORγ inverse agonist and inhibits TH17 cell differentiation and function. |
FB02411 | SR-1078 | 1246525-60-9 | SR-1078 is an agonist of RORα and RORγ and can increase transcriptional activity of RORα with 2 μM. |
FB13012 | SR 0987 | 303126-97-8 | SR 0987 is an agonist of T cell-specific RORγ (RORγt) with EC50 of 800 nM. It can induce IL-17 expression and decrease PD-1 expression in T cells. |
FB03200 | RORgamma-t-IN-1 | 1426802-50-7 | RORγt-IN-1 is a potent, orally bioavailable RORγt inhibitor with pIC50 of 8.4 and > 8.2 for RORγ FRET assay and Th17 assay. |
FB17951 | PF-06747711 | 1892576-58-7 | PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity. |
FB03350 | L 601920-0 | 20231-57-6 | L 601920-0 is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2. |
FB03263 | GSK2981278 | 1474110-21-8 | GSK2981278 is a retinoid-related orphan receptor gamma (RORy) modulator. |
FB12018 | GNE-6468 | 1677668-27-7 | GNE-6468 is a potent and selective RORγ(RORc) agonists with an EC50 value of 13 nM for HEK-293 cell. |
FB12016 | GNE-0946 | 1677667-24-1 | GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell. |
FB12219 | (±)-ML 209 | 1334526-14-5 | (±)-ML 209 is a RORγt inverse agonist with IC50 of 460 nM. |