Raf
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB01168 | ZM336372 | 208260-29-1 | ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM. |
| FB12347 | XRK3F2 | 2375193-43-2 | XRK3F2 is a p62-ZZ domain inhibitor which can blunt MM-induced Runx2 suppression and induce new bone formation and remodeling. |
| FB03116 | Vemurafenib | 918504-65-1 | Vemurafenib is a potent inhibitor of B-Raf V600E with IC50 of 31 nM in cell-free assay, and is 10-fold selective for B-Raf V600E over wild-type B-Raf in enzymatic assays while the cellular selectivity can exceed 100-fold. |
| FB08618 | TAK-632 | 1228591-30-7 | TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF with > 60 fold selectivity over VEGFR. |
| FB03005 | Sorafenib Tosylate | 475207-59-1 | Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively. Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro. |
| FB07969 | Sorafenib | 284461-73-0 | Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM in cell-free assays, respectively. |
| FB07148 | SB-590885 | 405554-55-4 | SB-590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases. |
| FB06990 | Ro 5126766 | 946128-88-7 | Ro 5126766 is a unique and allosteric MEK/RAF signaling inhibitor with IC50 values of 8.2, 19, 56 and 160nM for BRAFV600E mutant, BRAF, CRAF and MEK1, respectively. |
| FB10078 | RAF709 | 1628838-42-5 | RAF709 is an inhibitor of c-Raf and b-Raf with IC50 of 0.5 nM and 1.8 nM, respectively. |
| FB12147 | Praeruptorin B | 81740-07-0 | Praeruptorin B is extracted from umbelliferae peucedanum praeruptorum, it has found that praeruptorin B improves diet-induced hyperlipidemia and alleviates insulin resistance via regulating SREBP signaling pathway. |
| FB02831 | PLX8394 | 1393466-87-9 | PLX8394 is an inhibitor of B-Raf (V600E) with IC50 of 5 nM. |
| FB02830 | PLX7904 | 1393465-84-3 | PLX7904 is a Raf inhibitor, inhibits the growth of two melanoma cell lines (A375 and COLO829) and human colorectal cancer cell line COLO205 that expressed BRAFV600E with IC50 values of 0.17 μM, 0.53 μM, and 0.16 μM, respectively. |
| FB03820 | PLX4720 | 918505-84-7 | PLX 4720 is a potent and selective inhibitor of B-RafV600E (IC50=13 nM) and c-Raf-1Y340D/Y341D (IC50=6.7 nM), whth a 10-fold selectivity for B-RafV600E than wild-type B-Raf. |
| FB11936 | Paclitaxtide | N/A | Paclitaxtide is in phase III clinical trials for the treatment of breast cancer and non small cell lung cancer (NSCLC). |
| FB11555 | N-(3-Methoxybenzyl)oleamide | N/A | N-(3-Methoxybenzyl)oleamide can be isolated from the herbs of lepidium meyenii walp. |
| FB09454 | MLN2480 | 1096708-71-2 | MLN 2480 is a selective inhibitor of pan-Raf kinase with antitumor activity. |
| FB12460 | ML 786 2HCl | 1237536-18-3 | ML 786 2HCl is a potent Raf kinase inhibitor with IC50s of 2.1, 2.5 and 4.2 nM for B-RafV600E, C-Raf and wild-type B-Raf, respectively. |
| FB07882 | LY3009120 | 1454682-72-4 | LY3009120 is a small molecule that has been shown to be a pan-RAF inhibitor of all isoforms, inhibiting BRAFV600E, BRAFWT and CRAFWT with IC50 values of 5.8, 9.1 and 15 nM and blocking proliferation in both BRAF and RAS mutant cells. |
| FB11738 | LXH254 | 1800398-38-2 | LXH254 is an ATP-competitive inhibitor of Raf with anti-proliferative activity. Phase I. |
| FB16782 | LUT-014 | 2274819-46-2 | LUT-014 is a B-Raf inhibitor with an IC50 of 11.7 nM, and it is developed to reduce dose-limiting acneiform lesions associated EGFR inhibitors treatment. |
| FB16058 | rel-5-[[(1R,1aS,6bR)-1a,6b-Dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3,4-dihydro-1,8-naphthyridin-2(1H)-one | 1446090-77-2 | Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. |
| FB01701 | L-779450 | 303727-31-3 | L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. |
| FB00357 | Lifirafenib | 1446090-79-4 | In vitro, BGB-283 potently inhibits BRAFV600E-activated ERK phosphorylation and cell proliferation. |
| FB01564 | HG6-64-1 | 1315329-43-1 | HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor. |
| FB04806 | GW5074 | 220904-83-6 | GW5074 is an inhibitor of c-Raf1 kinase with IC50 of 9 nM. |
| FB05365 | GDC-0879 | 905281-76-7 | GDC-0879 is a potent, and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well, displaying no inhibition known to other protein kinases. |
| FB03363 | Encorafenib | 1269440-17-6 | Encorafenib is a potent and selective B-RafV600E inhibitor, with no significant activity observed against a panel of 100 kinases (IC50>900nM). |
| FB18055 | Donafenib | 1130115-44-4 | Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively. |
| FB07943 | Dabrafenib Mesylate | 1195768-06-9 | Dabrafenib mesylate is an inhibitor of raf kinase with IC50 values of 0.6 nM and 5.0 nM for B-Raf V600E and c-Raf, respectively. |
| FB00248 | Dabrafenib | 1195765-45-7 | Dabrafenib is a potent, selective and efficacious inhibitor of B-RafV600E with IC50 value of 0.7 nM, and less potent to B-Raf and C-Raf with IC50 values of 5.2 nM and 6.3 nM, respectively. |
| FB08612 | CEP-32496 | 1188910-76-0 | CEP-32496 is an inhibitor of BRAF V600E (IC50 = 14 nM), WT (IC50 = 34 nM) and c-Raf (IC50 = 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2. |
| FB00488 | CEP-32496 HCl | 1227678-26-3 | CEP-32496 HCl is a highly potent inhibitor of BRAF (V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively, displaying insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. |
| FB01405 | CCT196969 | 1163719-56-9 | CCT196969 is active against melanoma and colorectal cancer cell lines that are mutant for BRAF, but not cancer cells that are wild-type for BRAF and NRAS. CCT196969 induces caspase 3 and PARP cleavage, thus induces apoptosis. CCT196969 does not drive paradoxical pathway activation and inhibit MEK/ERK in BRAF and NRAS mutant melanoma. |
| FB03819 | BRAF Inhibitor | 918505-61-0 | BRAF inhibitor is a potent BRAF inhibitor. |
| FB16073 | BI-882370 | 1392429-79-6 | BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases[1]. |
| FB09556 | B-Raf Inhibitor | 1315330-11-0 | B-Raf inhibitor, a pyrazine and pyrrolo[2,3-b]pyridine derivative, is useful in the treatment of cancer and proliferative diseases. |
| FB00596 | B-Raf Inhibitor 1 | 1093100-40-3 | B-Raf inhibitor 1 is an inhibitor of B-Raf with IC50s ranging from 0.31 μM to 2 nM in cells assay. |
| FB07034 | B-Raf Inhibitor 1 2HCl | 1191385-19-9 | B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 μM and 2 nM for A375 proliferation and A375 p-ERK respectively. |
| FB01852 | B-Raf IN 1 | 950736-05-7 | B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM, equipotent against c-Raf (IC50= 25 nM). |
| FB12138 | AZ304 | 942507-42-8 | AZ304 is an inhibitor of BRAF and can target many kinases. The IC50s for wild type BRAF, V600E mutant BRAF and wild type CRAF are 79 nM, 38 nM and 68 nM, respectively. It can also inhibit p38 (IC50 = 6 nM) and CSF1R (IC50 = 35 nM). |
| FB09246 | AZ 628 | 878739-06-1 | AZ 628 is a pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. |