ATM/ATR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB08307 | VE-822 | 1232416-25-9 | VE-822 is an ATR inhibitor with IC50 of 19 nM in HT29 cells. |
| FB08535 | VE-821 | 1232410-49-9 | VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM. |
| FB02341 | Mirin | 1198097-97-0 | Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. |
| FB08347 | KU-60019 | 925701-46-8 | KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM. |
| FB08055 | KU-55933 | 587871-26-9 | KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. |
| FB01108 | CP-466722 | 1080622-86-1 | CP-466722, a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells. |
| FB07476 | Chloroquine Phosphate | 1446-17-9 | Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties and inhibits the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin. |
| FB07655 | Chloroquine Diphosphate | 50-63-5 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| FB16760 | Chloroquine Sulphate | 132-73-0 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| FB16863 | Chloroquine | 54-05-7 | Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug. |
| FB08941 | CGK733 | 905973-89-9 | CGK 733 is an inhibitor of ATM and ATR with IC50 of ~200 nM, also induces cell death in prematurely senescent breast cancer cells. |
| FB11194 | BAY-1895344 | 1876467-74-1 | BAY-1895344 is a potent and selective ATR inhibitor with IC50 of 7 nM. |
| FB02220 | AZD6738 | 1352226-88-0 | AZD6738 is a highly selective and potent inhibitor of ATR kinase activity with IC50 value of 1nM in isolated enzyme assay and showed inhibitory effect on ATR kinase-dependent cellular Chk1 phosphorylation with IC50 value of 74nM. |
| FB12816 | AZD1390 | 2089288-03-7 | AZD1390 is an ATM inhibitor with IC50 of 0.78 nM in cells. |
| FB09923 | AZD0156 | 1821428-35-6 | AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. |
| FB11938 | AZ32 | 2288709-96-4 | AZ32 is an ATM inhibitor with IC50 <6.2 nM in enzyme assays and 310 nM in cellular assays. |
| FB16068 | AZ31 | 2088113-98-6 | AZ31 is a potent and highly selective ATM inhibitor. |
| FB12189 | AZ 5704 | 1941214-06-7 | AZ 5704 is a potent and selective ATM kinase inhibitor with IC50 of 0.6 nM. |
| FB08619 | AZ 20 | 1233339-22-4 | AZ 20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM exhibiting 8-fold selectivity over mTOR (IC50=38 nM). |