P450
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB11144 | VT-1598 | 2089320-99-8 | VT1598 is a highly-selective, broad spectrum fungal CYP51 inhibitor, exhibiting excellent potency against yeast, dermatophyte, and mold fungal pathogens. |
| FB02810 | VT-464 Racemate | 1375603-36-3 | VT-464 racemate is the racemate form of VT-464, which is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM)inhibition. |
| FB10360 | VT-464 R-Enantiomer | 1375603-38-5 | VT-464 R-enantiomer is the R-enantiomer with unknown activity of VT-464, which is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM). |
| FB03317 | VT-464 | 1610537-15-9 | VT-464 is a potent CYP17 lyase inhibitor (h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. |
| FB10556 | Uniconazole | 83657-22-1 | Uniconazole inhibits CK biosynthesis by suppressing CYP735A activity in Arabidopsis. Uniconazole inhibits the biosynthesis of gibberellin (GA), and brassinosteroid (BR) and the catabolism of abscisic acid (ABA). |
| FB10356 | Talarozole R-Enantiomer | 870093-23-5 | Talarozole R-enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| FB10242 | Ramatroban | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| FB10162 | PF-4981517 | 1390637-82-7 | PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits > 500-fold selectivity over CYP3A5 and CYP3A7. |
| FB02619 | Ozagrel | 82571-53-7 | Ozagrel is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. |
| FB00110 | Ozagrel HCl | 78712-43-3 | Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. |
| FB10889 | Oteseconazole | 1340593-59-0 | Oteseconazole is a tetrazole antifungal agent potentially for the treatment of candidal vaginal infection by inhibiting sterol 14α-demethylase (CYP51). |
| FB06194 | Orteronel | 566939-85-3 | Orteronel is a highly selective inhibitor of human 17,20-lyase with IC50 of 38 nM, and exhibits > 1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4. |
| FB11146 | ONO-1301 | 176391-41-6 | ONO-1301 is a non-prostanoid prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. It is also a long-acting prostacyclin agonist loaded in PLGA microspheres prepared using different molecular weights of PLGA. |
| FB16787 | NVP-VID-400 | 174262-13-6 | NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1. |
| FB16360 | NTP42 | 2055599-51-2 | NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM. |
| FB02146 | Naringin | 10236-47-2 | Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| FB08558 | Naringin Dihydrochalcone | 18916-17-1 | Naringin dihydrochalcone is a sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes. |
| FB05552 | Memantine HCl | 41100-52-1 | Memantine HCl, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively, is used for the treatment of Alzheimer's disease. |
| FB18000 | Mefentrifluconazole | 1417782-03-6 | Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). |
| FB20364 | 17-ODYA | 34450-18-5 | LTB ω-hydroxylase inhibitor. |
| FB09470 | Ketoconazole | 65277-42-1 | Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 0.19 mM and 0.22 mM, respectively. |
| FB00829 | Itraconazole | 84625-61-6 | Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. |
| FB16215 | Sparteine | 492-08-0 | Inhibition of human CYP2D6 expressed in Escherichia coli JM109 |
| FB02440 | HET0016 | 339068-25-6 | HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. |
| FB20324 | 7-Ethoxyresorufin | 5725-91-7 | Fluorometric CYP450 substrate. |
| FB20345 | Methoxyresorufin | 5725-89-3 | Fluorometric CYP450 substrate. |
| FB01050 | Fluconazole | 86386-73-4 | Fluconazole, an inhibitor of CYP2C19, CYP2C9 and CYP3A4, is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. |
| FB12794 | Flavone | 525-82-6 | Flavone can effect CYP (P450) activity, it's a class of flavonoids with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc. |
| FB12162 | DMU2139 | 1821143-80-9 | DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM. |
| FB17558 | DMU2105 | 1031063-36-1 | DMU2105 is a potent CYP1B1 inhibitor with IC50 value of 10nM for human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™). |
| FB16557 | Dazoxiben HCl | 74226-22-5 | Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. |
| FB01978 | Dafadine-A | 1065506-69-5 | Dafadine-A, an analog of dafadine, is an inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans and also inhibits the mammalian ortholog of DAF-9 (CYP27A1). |
| FB11195 | CYP11B1 Inhibitor C25 | 2101952-78-5 | CYP11B1 inhibitor C25 is a CYP11B1 inhibitor of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushing’s disease. |
| FB08311 | Cobicistat | 1004316-88-4 | Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
| FB02062 | Chlorzoxazone | 95-25-0 | Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It is also a CYP2E1 inhibitor with IC50 value of 1.03μM. |
| FB11706 | CGS 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
| FB10353 | CDD3506 | 197913-15-8 | CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity. |
| FB10352 | CDD3505 | 173865-33-3 | CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepaticcytochrome P450IIIA (CYP3A)activity. |
| FB08275 | Carbosulfan | 55285-14-8 | Carbosulfan inhibits relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). |
| FB03021 | Benzbromarone | 3562-84-3 | Benzbromarone is a CYP2C9 inhibitor with Ki of 19.3 nM. |
| FB01907 | Baicalein | 491-67-8 | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. |
| FB09183 | ABT | 1614-12-6 | ABT is a non-specific cytochrome P450 (CYP) inhibitor. |
| FB00306 | Abiraterone Acetate | 154229-18-2 | Abiraterone Acetate is a potent CYP17A1 inhibitor with IC50 of 4 nM. |
| FB17233 | 6-Aminochrysene | 2642-98-0 | 6-aminochrysene was a potent inducer of CYP1A1 in rat. |
| FB17229 | 5-Aminomethyl-3-(pyridin-3-yl)isoxazole | 543713-43-5 | 5-Aminomethyl-3-(pyridin-3-yl)isoxazole |
| FB00904 | 3-Cyano-7-Ethoxycoumarin | 117620-77-6 | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage. |
| FB01997 | 25R-Inokosterone | 19682-38-3 | 25R-Inokosterone has a role on cytochrome P450 from a hormone-resistant cell line. |
| FB09961 | 1-Ethynylnaphthalene | 15727-65-8 | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1. |
| FB20342 | (S)-Mephenytoin | 70989-04-7 | (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase. |