CAS:181695-72-7Valdecoxib

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Synonyms: SC 65872

Valdecoxib is a potent COX inhbitor that selectively inhibitors COX-2 with IC50 of 5 nM.

规格	价格	促销价格	库存

18817579266

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18817579266

立即询价

实验数据

技术信息

CAS号

181695-72-7

储存条件

分子式

C16H14N2O3S

运输

蓝冰

分子量

314.36

别名

SC 65872

溶解度

动物实验配方

0.5% methylcellulose+0.2% Tween 80+water

19 mg/mL

suspension

生物活性

靶点 COX2

IC50:5nM
描述Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively^[3]. Valdecoxib inhibited LPS-induced proliferation of endothelial cells and bFGF secretion in a dose-dependent manner. Valdecoxib stimulated VEGF formation via HMEC-1 (human microvascular endothelial cells) under inflammatory conditions^[4]. Valdecoxib (10 mg/kg, i.p.) significantly attenuates the behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice^[5]. Valdecoxib has the symptomatic treatment of osteoarthritis or rheumatoid arthritis (10 to 20 mg once a day) and for the treatment of primary dysmenorrhea (40 mg once a day). Valdecoxib is as efficacious as conventional non-COX-2 selective NSAIDs, but offers the advantage of a much better gastrointestinal tolerance^[6]. In acute post-surgical pain, valdecoxib provided similar pain relief to oxycodone/paracetamol, had a long duration of action, a rapid onset of analgesia and was opioid-sparing^[7].