Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane. The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family. In the brain, EAATs remove glutamate from the synaptic cleft and extrasynaptic sites via glutamate reuptake into glial cells and neurons, while VGLUTs move glutamate from the cell cytoplasm into synaptic vesicles. Glutamate transporters also transport aspartate and are present in virtually all peripheral tissues, including the heart, liver, testes, and bone. They exhibit stereoselectivity for L-glutamate but transport both L-aspartate and D-aspartate.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB17163 | DL-TBOA | 205309-81-5 | DL-TBOA is a competitive and non-transportable blocker of excitatory amino acid transporters with IC50 values of 70, 6, 6, 4.4 and 3.2 μM for EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5 respectively. |
| FB12548 | Chicago Sky Blue 6B | 2610-05-1 | Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles and also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 0.81 μM. |
| FB17161 | (±)-HIP-B | 227619-65-0 | (±)-HIP-B is non-competitive excitatory amino acid transporter (EAAT) blocker. |
| FB17162 | (±)-HIP-A | 227619-64-9 | (±)-HIP-A is a non-competitive blocker of excitatory amino acid transporter (EAAT). |