HDAC
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10832 | WT161 | 1206731-57-8 | WT161 selectively inhibits HDAC6 that exhibits effective anti-tumor activities in multiple myeloma. |
| FB12105 | Tucidinostat | 1616493-44-7 | Tucidinostat is an inhibitor of HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor with IC50s of 95, 160, 67 and 78 nM, espectively. |
| FB09987 | TMP195 | 1314891-22-9 | TMP195 is an inhibitor of class IIa histone deacetylase (HDAC) with IC50 of 15 nM - 59 nM for HDAC4, 5, 7 and 9. |
| FB16072 | Tinostamustine HCl | 1793059-58-1 | Tinostamustine is an alkylatlng histone-deacetylase inhibitor (HDACi) fusion molecule. It is a functional pan-histone-deacetylase inhibitor and is assumed to potentiate the alkylating activity of the compound and/or may help to overcome resistance to other therapeutic agents. |
| FB01060 | Sulforaphane Racemate | 4478-93-7 | Sulforaphane, a natural product isolated and purified from the seeds of Brassica oleracea L. var. botrytis L. with neuroprotective, anti-inflammatory and antitumor effects, inhibits TPA-induced NF-κB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKα and NAK-IKKβ. |
| FB11578 | SR-4370 | 1816294-67-3 | SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. |
| FB15761 | SIS17 | 2374313-54-7 | SIS17 is a specific HDAC11 inhibitor with IC50 value of 0.83μM for inhibition of the demyristoylation HDAC11 substrate, serine hydroxymethyl transferase 2. |
| FB02795 | RGFP966 | 1357389-11-7 | RGFP966 is specific inhibitor of HDAC3 with an IC50 of 0.08 μM and no effective inhibition of any other HDAC at concentrations up to 15 μM (measured by enzymatic activity of recombinant human HDACs). |
| FB09938 | RGFP966 Racemate | 1396841-57-8 | RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM in cell-free assay, exhibits > 200-fold selectivity over other HDAC. |
| FB01660 | RG2833 | 1215493-56-3 | RG2833 is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
| FB06864 | Resminostat | 864814-88-0 | Resminostat is a potent inhibitor of HDAC1/3/6 (IC50=43-72 nM) and less potent to HDAC8 with IC50 of 877 nM. |
| FB02326 | Resminostat HCl | 1187075-34-8 | Resminostat HCl is a potent inhibitor of HDAC1/3/6 (IC50=43-72 nM) and less potent to HDAC8 with IC50 of 877 nM. |
| FB12388 | Remetinostat | 946150-57-8 | Remetinostat, also called SHP-141, is an inhibitor of HDAC with antineoplastic activity. |
| FB09955 | Quisinostat 2HCl | 875320-31-3 | Quisinostat 2HCl is a second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11, greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. |
| FB11757 | Pomiferin | 572-03-2 | Pomiferin, a flavonoid from the fruits of Maclura pomifera, acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 µM). |
| FB10247 | Pimelic Diphenylamide 106 Analog | 2070015-24-4 | Pimelic diphenylamide 106 Analog is an analog of Pimelic Diphenylamide 106 with unknown biological activity. Pimelic Diphenylamide 106 is a class I HDAC inhibitor, demonstrating no activity against class II HDACs. 106 is a slow, tight-binding inhibitor of HDACs 1, 2, and 3 with preference toward HDAC3 with Ki of approximately 14 nm, 15 times lower than the Ki for HDAC1. |
| FB00646 | NKL 22 | 537034-15-4 | NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM. |
| FB12723 | TCS HDAC6 20b | 956154-63-5 | NCT-14b is a selective HDAC6 inhibitor. It inhibits cell growth of α-positive MCF-7 breast cancer cells treated with estrogen but not untreated cells. |
| FB12439 | MC 1742 | 1776116-74-5 | MC 1742 is a potent class I and IIb HDAC inhibitor with IC50s of 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively. |
| FB03191 | LMK-235 | 1418033-25-6 | LMK235 is a HDAC inhibitor of human HDAC4 and HDAC5 with IC50 values of 0.49 μM (A2780) and 0.32 μM (A2780 CisR). |
| FB15654 | JAK/HDAC-IN-1 | 2284621-75-4 | JAK/HDAC-IN-1 is a potent JAK2/HDAC dual inhibitor with improved antiproliferative and proapoptotic activities over SAHA and ruxolitinib in several hematological cell lines. |
| FB09943 | HPOB | 1429651-50-2 | HPOB is a selective inhibitor of HDAC6 with IC50 of 56 nM. |
| FB11638 | HDAC6-IN-1 | 1815580-06-3 | HDAC6-IN-1 is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively |
| FB11879 | HDAC6 Degrader 9c | 2235382-05-3 | HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line. |
| FB01927 | HDAC-IN-3 | 1018673-42-1 | HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor. |
| FB02405 | HDAC-IN-1 | 1239610-44-6 | HDAC-IN-1 is a chemical analog of MC 1568, which is a potent and selective class IIa HDACs inhibitor. |
| FB11174 | HDAC Inhibitor C4j | 2098896-13-8 | HDAC inhibitor C4j is a potent HDAC inhibitor in the cellular HDAC assay, revealed remarkable chemosensitizing properties and enhanced the cisplatin sensitivity of the cisplatin-resistant head-neck cancer cell line Cal27CisR by almost sevenfold. Furthermore, 4j almost completely reversed the cisplatin resistance in Cal27CisR. |
| FB01274 | HDAC Inhibitor C001 | 1609389-52-7 | HDAC inhibitor C001 is an inhibitor of HDACs with IC50 of 4 nM (HDAC1), 15 nM (HDAC2), 114 nM (HDAC3), and can increase Gata2 expression, which may be useful in treatment of Gata2-deficiency-associated diseases, including leukemia and other blood cell disorders. |
| FB06160 | Givinostat | 497833-27-9 | Givinostat is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM,respectively. |
| FB04059 | Givinostat HCl | 199657-29-9 | Givinostat HCl is a potent HDAC inhibitor for Maize HD2, HD1-B and HD1-A with IC50 of 10 nM, 7.5 nM and 16 nM, respectively. |
| FB07175 | Droxinostat | 99873-43-5 | Droxinostat is an inhibitor of HDAC3, HDAC6, and HDAC8 with IC50 of 16.9, 2.47 and 1.46 μM, respectively. |
| FB06926 | Domatinostat | 910462-43-0 | Domatinostat is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). |
| FB11033 | CM-272 | 1846570-31-7 | CM-272 is a potent, selective and reversible dual small molecule against G9a and DNMTs activity. |
| FB11285 | CG200745 | 936221-33-9 | CG200745 is a hydroxamate-based pan-histone deacetylase inhibitor. |
| FB01659 | BRD73954 | 1440209-96-0 | BRD73954 is a selective inhibitor of HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. |
| FB11349 | BRD3308 | 1550053-02-5 | BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs. |
| FB12224 | BRD 9757 | 1423058-85-8 | BRD 9757 is a potent and selective HDAC6 inhibitor with IC50 of 30 nM. |
| FB12230 | BRD 4354 | 315698-07-8 | BRD 4354 is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively. |
| FB15604 | BRD 4354 Ditrifluoroacetate | 2444837-63-0 | BRD 4354 Ditrifluoroacetate is an inhibitor of HDAC5 and HDAC9 with IC50s of 0.85 and 1.88 μM respectively. |
| FB07466 | Biphenyl-4-sulfonyl Chloride | 1623-93-4 | Biphenyl-4-sulfonyl chloride is an inhibitor of HDAC and it has synthetic applications in palladium-catalyzed desulfitative C-arylation. |
| FB03328 | BG45 | 926259-99-6 | BG45 is a selective inhibitor for HDAC3 with IC50 of 289 nM. |
| FB10752 | Belinostat | 866323-14-0 | Belinostat is a pan-HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors. |
| FB09891 | Apicidin | 183506-66-3 | Apicidin is a potent histone deacetylase (HDAC) inhibitor with antiangiogenic and anti-invasive activity, which blocks proliferation of human stomach and breast cancer cells, and induces apoptosis and autophagy in human oral squamous carcinoma cells. |
| FB17731 | ACY-775 | 1375466-18-4 | ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM. |
| FB07195 | ACY-738 | 1375465-91-0 | ACY-738 inhibits HDAC6 with IC50 value of 1.7 nM. |
| FB02324 | 4SC-202 | 1186222-89-8 | 4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes (NO HDAC8) with IC50s of 1.2/1.12/0.57 μM for HDAC1/2/3, demonstrating high selectivity over ClassIIa/IIb/III HDACs. |
| FB12988 | 4-Phenylbutanoic acid | 1821-12-1 | 4-Phenylbutanoic acid is an inhibitor of HDAC which can regulate gene transcription with anti-tumor and neuroprotective effects. |
| FB00620 | 4-Hydroxybenzoic Acid | 99-96-7 | 4-Hydroxybenzoic acid, a natural product isolated and purified from the herbs of Rhodiola crenulata, positively regulates the expression of gum cluster to promote EPS production in PXO99A, and its derivatives have potential to as pan-HDAC inhibitors with anticancer properties. |
| FB20312 | 1-Naphthohydroxamic acid | 6953-61-3 | 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity, But it can induce tubulin acetylation. |
| FB08201 | (R)-Sulforaphane | 142825-10-3 | (R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer. |