CAS:51803-78-2Nimesulide

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Synonyms: Flogovital;R805

Nimesulide is a COX2 selective inhibitor with IC50 of 26 μM.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

51803-78-2

储存条件

分子式

C13H12N2O5S

运输

蓝冰

分子量

308.31

别名

Flogovital;R805

溶解度

动物实验配方

生物活性

描述Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties^[3]. Nimesulide, but not indomethacin, reduced the fever induced by MIP-1alpha, PGF(2alpha), CRF or ET-1. Plasma TNF-alpha levels in LPS-treated rats were also reduced by nimesulide^[4]. Nimesulide (10 µM) effectively decreases VEGF in endometrium cancer cells, and shows no effect on that in normal cells. Nimesulide (10 and 50 µM) dramatically decreases MCP-1 levels in normal cell, and such an effect is also observed with 10 µM in cancer cells. In addition, Nimesulide (50 µM) potently affects IL-8 level in normal cells, but causes no changes in cancer cells^[5].