OX Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB17743 | YNT 185 | 1804978-81-1 | YNT 185 is potent and selective orexin OX2 receptor agonist with EC50 of 28 nM at human OX2 expressed in CHO cells. YNT 185 displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). |
| FB10286 | TCS-OX2-29 | 372523-75-6 | TCS-OX2-29 is a potent and selective orexin 2 (OX2) receptor antagonist with IC50 of 40 nM. |
| FB00707 | TCS 1102 | 916141-36-1 | TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). |
| FB00159 | Suvorexant | 1030377-33-3 | Suvorexant is a potent dual OX receptor antagonist with Ki of 0.55 nM and 0.35 nM for OX1 receptor and OX2 receptor, respectively. |
| FB10817 | Seltorexant | 1293281-49-8 | Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species. |
| FB06143 | SB-674042 | 483313-22-0 | SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76 nM) exhibiting 100-fold selectivity for OX1 over OX2 receptors. |
| FB09443 | SB-649868 | 380899-24-1 | SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). |
| FB00075 | SB-408124 | 288150-92-5 | SB-408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, and exhibits 50-fold selectivity over OX2 receptor. |
| FB03214 | SB-408124 HCl | 1431697-90-3 | SB-408124 HCl is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively and exhibits 50-fold selectivity over OX2 receptor. |
| FB06693 | SB-334867 | 249889-64-3 | SB-334867 is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. |
| FB06692 | SB-334867 Free Base | 792173-99-0 | SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with pKb of 7.2. |
| FB04013 | Orexin 2 Receptor Agonist | 1796565-52-0 | Orexin 2 receptor agonist is a potent and selective OX2R agonist with EC50 of 23 nM. |
| FB09442 | MK-6096 | 1088991-73-4 | MK-6096 is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor (< 3 nM in binding). |
| FB07055 | MK-3697 | 1224846-01-8 | MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. |
| FB10083 | MK-1064 | 1207253-08-4 | MK-1064 is a selective orexin 2 receptor antagonist(2-SORA) for the research of insomnia. |
| FB02804 | Lemborexant | 1369764-02-2 | Lemborexant is a dual antagonist of the orexin OX1 and OX2 receptors which is under development for treatment of insomnia. |
| FB02583 | Almorexant | 871224-64-5 | Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
| FB09444 | Almorexant HCl | 913358-93-7 | Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. |
| FB11126 | ACT-541468 | 1505484-82-1 | ACT-541468 is a dual orexin receptor antagonist used for treating insomnia. |
| FB10815 | ACT-462206 | 1361321-96-1 | ACT-462206 is a potent and brain-penetrant dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively), and it exhibits anxiolytic-like properties in vivo. |