CAS:36330-85-5Fenbufen

Synonyms: CL-82204

Fenbufen is a phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

立即询价

实验数据

技术信息

CAS号

36330-85-5

储存条件

分子式

C16H14O3

运输

蓝冰

分子量

254.28

别名

CL-82204

溶解度

动物实验配方

生物活性

描述Fenbufen is a non-selective non-steroidal anti-inflammatory drug (NSAID), used to treat acute and chronic painful conditions. Fenbufen at both doses (800 mg or 400 mg, oral) had apparent analgesic efficacy^[3]. Fenbufen is a phenylalkanoic acid derivative with analgesic and anti-inflammatory activity. At a daily dosage of 600 mg, fenbufen is comparable with aspirin 3.6 g or indomethacin 75 mg in osteoarthritis^[4]. Like clinically used nonsteroidal anti-inflammatory drugs, Fenbufen shows activity in a wide spectrum of laboratory tests in mice, rats, guinea pigs, and dogs. Fenbufen has a long duration of anti-inflammatory and analgesic activity. Mechanistic studies indicate that fenbufen has no intrinsic effect on cyclooxygenase activity, whereas its major metabolite, biphenylacetic acid, is a potent inhibitor of prostaglandin synthesis. Comparative studies in the type II collagen arthritis model indicate that the anti-inflammatory properties of fenbufen are more potent than those of a second nonsteroidal anti-inflammatory drug, sulindac^[5].