MMP
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10345 | TAPI-2 | 187034-31-7 | TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP. |
| FB09945 | TAPI-1(Random Configuration) | 171235-71-5 | TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. |
| FB03957 | TAPI-1 | 163847-77-6 | TAPI-1 is a specific TACE (TNF-α-converting enzyme) inhibitor. |
| FB11138 | TACE Inhibitor C3 | 1219812-22-2 | TACE inhibitor C3 is a prodrug of hydantoin based TNF-α converting enzyme (TACE) inhibitor. |
| FB15546 | T-26c | 869296-13-9 | T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1]. |
| FB12654 | SD 2590 HCl | 226395-93-3 | SD-2590 HCl is an inhibitor of MMP-2,-3, -9, -8, 13, and -14. |
| FB04593 | SB-3CT | 292605-14-2 | SB-3CT is a potent, competitive and non-selective MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. |
| FB11630 | S-methyl-KE-298 | 143584-75-2 | S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells. |
| FB09829 | S 3304 | 203640-27-1 | S 3304 is a novel MMP inhibitor. |
| FB03323 | Prinomastat | 192329-42-3 | Prinomastat is a spectrum inhibitor of MMP with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9 respectively. |
| FB08373 | Pimaric Acid | 127-27-5 | Pimaric acid is a natural product isolated and purified from the herbs of Aralia cordata having a potent anti-atherosclerotic activity with inhibitory action on matrix metalloproteinase-9 production and cell migration in TNF-α-induced human aortic smooth muscle cells. |
| FB10180 | Phosphoramidon Disodium | 164204-38-0 | Phosphoramidon disodium is a metalloendopeptidase inhibitor, widely used as a biochemical tool. |
| FB08478 | NSC 405020 | 7497-07-6 | NSC 405020 is a non-catalytic Membrane type-1 MMP inhibitor with IC50 > 100 μM. |
| FB10925 | MMP13-In-1 | 935759-55-0 | MMP13-In-1 is a selective Matrix Metalloproteinase (MMP)-13 inhibitors. |
| FB16519 | MMP-9-IN-1 | 502887-71-0 | MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor that selectively targets the hemopexin (PEX) domain of MMP-9. |
| FB00047 | Marimastat | 154039-60-8 | Marimastat is a competitive and broad-spectrum MMP inhibitor with IC50 values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respectively. |
| FB04291 | Isoginkgetin | 548-19-6 | Isoginkgetin is a MMP-9 inhibitor isolated and purified from the leaves of Ginkgo biloba L., also a Pre-mRNA Splicing inhibitor with IC 50 of 30 μM. |
| FB12713 | T 26c Disodium Salt | 869298-22-6 | Highly potent and selective MMP13 inhibitor |
| FB02849 | GM6001 | 142880-36-2 | GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. |
| FB02849 | GM6001 | 142880-36-2 | GM6001 is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, 0.36 nM, respectively. |
| FB06622 | Ginsenoside CK | 39262-14-1 | Ginsenoside CK, a natural product isolated and purified from the roots of Panax ginseng C.A.Mey., is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. |
| FB00718 | GI 254023X | 260264-93-5 | GI 254023X is a potent and selective ADAM10 metalloproteinase inhibitor. |
| FB15358 | EGTA | 67-42-5 | EGTA is a calcium chelating agent, it's also a useful chemical in a variety of buffers. It also inhibits the zinc-dependent endopeptidases, MMPs. |
| FB04045 | CTS-1027 | 193022-04-7 | CTS-1027 is a potent small molecule inhibitor of MMPs (IC50=0.4 nM/0.6 nM for MMP2/MMP13), displaying > 1,000 fold selectivity over MMP1. |
| FB01393 | CL-82198 | 307002-71-7 | CL-82198 is a selective inhibitor of MMP-13. |
| FB02719 | Batimastat Sodium | 130464-84-5 | Batimastat sodium is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. |
| FB09420 | Batimastat | 130370-60-4 | Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. |
| FB05132 | Aderbasib | 791828-58-5 | Aderbasib is a sheddase inhibitor, is also an orally bioavailable inhibitor of the ADAM (A disintegrin and metalloprotease) family of multifunctional membrane-bound proteins with potential antineoplastic activity. |
| FB11217 | ADAMTS Inhibitor C7 | 1607004-34-1 | ADAMTS inhibitor C7 is an inhibitor of aggrecanase 1 and 2 (ADAMTS-4 and ADAMTS-5) had good oral pharmacokinetics in rats and showed efficacy in a rat chemical model of os-teoarthritis. |
| FB16148 | Abametapir | 1762-34-1 | Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. In vitro and ex vivo research has demonstrated that abametapir not only kills the lice, but also prevents hatching of their eggs. Xeglyze Lotion is emerging as a differentiated development candidate to treat head lice infestations. |
| FB20366 | PD 166793 | 199850-67-4 | Broad spectrum MMP inhibitor |
| FB16639 | JNJ0966 | 315705-75-0 |