Src
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00700 | WH-4-023 | 837422-57-8 | WH-4-023 is an inhibitor of Lck and Src with IC50 of 2 nM, 6 nM, respectively. |
| FB02792 | WEHI-345 Analog | 1354825-62-9 | WEHI-345 analog is a Src inhibitor. |
| FB02027 | TG 100801 | 867331-82-6 | TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src family kinases with IC50 values of 2/7/2/1/0.5 nM of VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. |
| FB06875 | TG 100572 | 867334-05-2 | TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. |
| FB06874 | TG 100572 HCl | 867331-64-4 | TG 100572 HCl is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. |
| FB02783 | T338C Src-IN-2 | 1351927-00-8 | T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM and also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM. |
| FB02782 | T338C Src-IN-1 | 1351926-90-3 | T338C Src-IN-1 is a potent mutant-Src T338C inhibitor and exhibits the most potent inhibition of T338C (IC50=111 nM) relative to WT c-Src(10-fold increase). |
| FB04900 | SU6656 | 330161-87-0 | SU 6656 is an inhibitor of Src kinases and can target Src, Yes, Lyn, and Fyn with IC50 of 280 nM, 20 nM, 130 nM, 170 nM, respectively. |
| FB00222 | Src Inhibitor 1 | 179248-59-0 | Src inhibitor 1 is an inhibitor of Src and Lck with IC50 of 44 nM and 88nM. |
| FB01373 | Saracatinib | 379231-04-6 | Saracatinib is Src inhibitor with IC50 of 2.7 nM. |
| FB15228 | RK 24466 | 213743-31-8 | RK-24466 is an inhibitor of Lck (64-509) and LckCD isoforms with IC50s of <2 nM. |
| FB08526 | PP2 | 172889-27-9 | PP2 is a ATP-competitive inhibitor of the Src family of protein tyrosine kinases. The IC50s for p56lck, p59fynT, Hck, Src are 4 nM, 5 nM, 5 nM, 100 nM, respectively. |
| FB08525 | PP1 | 172889-26-8 | PP1 is a selective inhibitor of Src and Lck/Fyn with IC50 of 5 nM, 6 nM, respectively. |
| FB07543 | PD173955 | 260415-63-2 | PD173955 is an src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase and is less potent for FGFRα and no activity on InsR and PKC. |
| FB12482 | PD 166285 2HCl | 212391-63-4 | PD 166285 inhibited Src nonreceptor tyrosine kinase, fibroblast growth factor receptor-1, epidermal growth factor receptor and platelet-derived growth factor receptor beta subunit (PDGFR-beta), tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 8.4 +/- 2.3 nM (n = 6), 39.3 +/- 2.8 nM (n = 16), 87.5 +/- 13.7 nM (n = 6) and 98.3 +/- 7.9 nM (n = 16), respectively. |
| FB02299 | MCB-613 | 1162656-22-5 | MCB-613 is a stimulator of steroid receptor coactivator (SRC). |
| FB01614 | Lck Inhibitor | 847950-09-8 | Lck inhibitor is a class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM. |
| FB06987 | Lck Inhibitor 2 | 944795-06-6 | Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively. |
| FB10062 | KX2-391 Mesylate | 1080645-95-9 | KX2-391 mesylate is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. |
| FB06774 | KX2-391 | 897016-82-9 | KX2-391 is an inhibitor of Src with IC50 of 9 nM-60 nM in cancer cells. It is the first clinical and peptidomimetic class Src inhibitor. |
| FB07457 | KX2-391 2HCl | 1038395-65-1 | KX2-391 2HCl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. |
| FB08655 | KX1-004 | 518058-84-9 | KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL. |
| FB08680 | KB SRC 4 | 1380088-03-8 | KB SRC 4 is a potent and selective c-Src inhibitor (Ki = 44 nM) and does not inhibit c-Abl at concentrations up to 125 μM. |
| FB16836 | Hck-IN-1 | 1473404-51-1 | Hck Blocker compound B9 is a Nef-dependent Hck blocker with IC50 value of 2.8μM for Nef-Hck complex but >20μM for Hck alone. It binds directly to Nef via a pocket formed by the Nef dimerization interface and disrupts Nef dimerization in cells. |
| FB18052 | CH6953755 | 2055918-71-1 | CH6953755 is a selective inhibitor of YES1 kinase with IC50 of 1.8 nM. |
| FB09340 | Bosutinib | 380843-75-4 | Bosutinib is an inhibitor of Src and Abl with IC50 of 1.2 nM and 1 nM. |
| FB06152 | AZM475271 | 476159-98-5 | AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM showing no inhibitory activity on Flt3, KDR, Tie-2. |
| FB08062 | AMG-47a | 882663-88-9 | AMG-47a is a Lck inhibitor that can decrease T cell proliferation with anti-inflammatory activity. |
| FB06879 | A-770041 | 869748-10-7 | A-770041 is selective and orally active Src-family Lck inhibitor and is a 147 nM inhibitor of Lck(1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. |
| FB04925 | A 419259 | 364042-47-7 | A 419259 is an apoptosis inducing agent that inhibits Src family kinases (c-Src) and also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation. |
| FB03227 | A 419259 3HCl | 1435934-25-0 | A 419259 3HCl is a broad-spectrum pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family with IC50 of 9 nM, < 3 nM and < 3 nM for Src, Lck and Lyn, respectively. |
| FB09128 | 7-Hydroxy-4-chromone | 59887-89-7 | 7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM. |
| FB01277 | 1-Naphthyl PP1 | 221243-82-9 | 1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). |
| FB08026 | 1-Naphthyl PP1 HCl | 956025-47-1 | 1-Naphthyl PP1 HCl is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). |