CAS:59804-37-4Tenoxicam

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Tenoxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

59804-37-4

储存条件

分子式

C13H11N3O4S2

运输

蓝冰

分子量

337.37

别名

溶解度

DMSO	55.0 mg/mL (163.0 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	1.1 mg/mL	clear
PO	0.5% CMC-Na	35 mg/mL	suspension

生物活性

描述Tenoxicam is an oxicam preferentially cyclooxygenase-1 (COX-1) inhibitor. Tenoxicam may have antioxidant effects, and that celecoxib and tenoxicam may reduce nitrite levels, indicating an alteration of NO (nitric oxide) pathways^[3]. Tenoxicam was administered intraperitoneally immediately after BCAO( both common carotid arteries). Histological analyses show that ischemia produced significant striatal as well as hippocampal lesions which were reversed by the Tenoxicam treatment. Tenoxicam also significantly reduced, to control levels, the increased myeloperoxidase activity in hippocampus homogenates observed after ischemia^[4]. Additionally, apart from oral use, tenoxicam is also applied as an intra-articular treatment option to minimize gastrointestinal side effects of NSAIDs^[5].