CAS:189954-96-9Firocoxib

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Synonyms: ML 1785713

Firocoxib is a potent and selective COX2 inhibitor with IC50 of 0.13 μM.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

189954-96-9

储存条件

分子式

C17H20O5S

运输

蓝冰

分子量

336.40

别名

ML 1785713

溶解度

DMSO	51.0 mg/mL (151.6 mM)

动物实验配方

生物活性

靶点 COX2

IC50:0.13μM
描述The COX‐2 isoform is constitutively expressed in a range of tissues and organs, and it is primarily induced by damage or tissue injury as a proinflammatory inducible enzyme and is responsible for the production of inducible enzymes which are converted into various eicosanoids^[3]. Firocoxib is a COX-2 selective NSAID. Cats receiving 3 mg/kg firocoxib had lower postoperative pain scores (both Colorado pain scale scores and composite pain scores) than those in the control group^[4]. Treatment with firocoxib orally at a dose rate of 5.7 to 8.5 mg/kg prior to induction of acute arthritis in dogs resulted in a high level of analgesia from the first post-treatment assessment at 3.5 h through 24 h post-treatment^[5].