CAS:26159-34-2Naproxen sodium

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Synonyms: RS-3650

Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

26159-34-2

储存条件

分子式

C14H13NaO3

运输

蓝冰

分子量

252.24

别名

RS-3650

溶解度

DMSO	3.0 mg/mL (11.9 mM)
Ethanol	Insoluble

动物实验配方

生物活性

描述Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively^[3]. JNJ7777120 (40 mg/kg b.wt.) and naproxen (21 mg/kg b.wt.) exert an anti-inflammatory and antifibrotic effect that is increased by their combination^[4]. The IC50 values (95% CI) of naproxen for analgesia [27 (0 - 130) μM], antipyretics [40 (30 – 65] μM) and inhibition of PGE2 [13 (6 – 45] μM) were in similar range, whereas inhibition of TXB2 [5 (4 - 8) μM] was observed at lower concentrations. Variability in the behavioral measurement of analgesia was larger than for the other endpoints^[5].