P-gp
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB09124 | Zosuquidar | 167354-41-8 | Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60% at 2 and 10μM and had no effect at 0.08 and 0.4μM (measured by P-gp ATPase activity). |
| FB03395 | Zosuquidar 3HCl | 167465-36-3 | Zosuquidar 3HCl is the 3HCl form of Zosuquidar. Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60% at 2 and 10μM and had no effect at 0.08 and 0.4μM. |
| FB00806 | Valspodar | 121584-18-7 | Valspodar is a P-glycoprotein (P-gp) inhibitor widely used in preclinical and clinical studies for overcoming multidrug resistance (MDR). |
| FB06220 | Tariquidar Methanesulfonate Hydrate | 625375-83-9 | Tariquidar methanesulfonate is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1±0.9 nM). |
| FB09218 | Tariquidar | 206873-63-4 | Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 5.1 nM, reverses drug resistance in MDR cell Lines. |
| FB08482 | SC144 | 895158-95-9 | SC144 showed its function through both exhibiting potent cytotoxicity, by itself or synergism with other compounds, against a panel of drug-sensitive and drug-resistant cancer cell lines, and targeting to gp130. |
| FB06943 | SC144 HCl | 917497-70-2 | SC144 HCl is the first-in-class orally active small-molecule gp130 inhibitor (IC50 = 0.72 μM) which blocks cytokine-triggered gp130 signaling. |
| FB16612 | RCGD423 | 108237-91-8 | RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair. |
| FB07887 | HM30181 | 849675-66-7 | HM30181 is a potent and selective inhibitor of P-glycoprotein. |
| FB10814 | Heliosterpenoid B | N/A | Heliosterpenoid B is a natural product isolated and purfied from the whole plants of Euphorbia helioscopia, being potent inhibitors of P-glycoprotein (ABCB1). |
| FB10813 | Heliosterpenoid A | 2109805-68-5 | Heliosterpenoid A is a natural product isolated and purfied from the whole plants of Euphorbia helioscopia, being potent inhibitors of P-glycoprotein (ABCB1) and exhibiting cytotoxicity against MDA-MB-231 cell lines. |
| FB12727 | UCLA GP130 2 | 339303-87-6 | gp130-agonist-2 is a brain penetrant gp130 agonist which protects against NMDA-induced toxicity and increases STAT3 phosphorylation. |
| FB05437 | Epimedokoreanin B | 161068-53-7 | Epimedokoreanin B is a natural product isolated and purified from the herbs of Epimedium brevicornum. |
| FB01263 | Elacridar | 143664-11-3 | Elacridar is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. |
| FB03069 | Elacridar HCl | 143851-98-3 | Elacridar HCl is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-gp to investigate the role of transporters in the disposition of various test molecules. |
| FB02711 | Dofequidar | 129716-58-1 | Dofequidar is a quinoline compound, which can reverse P-glycoprotein (P-gp)-mediated MDR. |
| FB03287 | Dofequidar Fumarate | 153653-30-6 | Dofequidar fumarate, an orally active quinoline compound, has been reported to overcome MDR by inhibiting ABCB1/P-gp, ABCC1/MDR-associated protein 1, or both. |
| FB12342 | CP 100356 HCl | 142715-48-8 | CP 100356 HCl is a high affinity P-glycoprotein (P-gp) inhibitor with Kis of 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms. |