CAS:36322-90-4Piroxicam

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Synonyms: CP-16171

Piroxicam is a selective COX1 inhibitor with anti-inflammatory effects.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

36322-90-4

储存条件

分子式

C15H13N3O4S

运输

蓝冰

分子量

331.35

别名

CP-16171

溶解度

动物实验配方

生物活性

靶点 COX

IC50:6mM
描述Piroxicam is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC50s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively^[3]. Piroxicam (0.3 mg/kg qd 24-h p.o.) reduces tumor volume in 12 of 18 dogs, and such and effect is via induction of apoptosis and reduction in urine basic fibroblast growth factor concentration^[4]. Piroxicam (167, 333, 500 μM) decreases cell population of T24 and the 5637 cells. Piroxicam (500 μM) also reduces the cell viability of T24 and 5637 cell, and is significantly effective when combined with 0.05 μM carboplatin. The combination also inhibits Ki-67 expression in booth cells. In vitro combination of carboplatin and piroxicam produced a more potent antiproliferative effect when compared to single drugs^[5].