CAS:68767-14-6Loxoprofen

您的位置 : 首页 / Immunology/Inflammation / COX / Loxoprofen

Synonyms: Koloxo

Loxoprofen is a non-steroidal anti-inflammatory drug (NSAID) and propionic acid derivative.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

68767-14-6

储存条件

分子式

C15H18O3

运输

蓝冰

分子量

246.30

别名

Koloxo

溶解度

动物实验配方

生物活性

描述Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the treatment of pain and inflammation caused by chronic and transitory conditions. In addition, LOX can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP) ^[3]. Loxoprofen (Loxonin(®), Loxonin(®) Pap, Loxonin(®) Tape) is a prodrug-type NSAID that is available in several formulations, including 60 mg tablets, 100 mg hydrogel patches and 50 or 100 mg tape. Loxoprofen is a useful analgesic option for patients with pain and inflammation, with topical loxoprofen potentially reducing the risk of gastrointestinal, cardiovascular and renal complications associated with oral NSAID use^[4]. The uptake of loxoprofen into Caco-2 cells was pH- and concentration-dependent, and was described by a Michaelis-Menten equation with passive diffusion (Km : 4.8 mm, Vmax : 142 nmol/mg protein/30 s, and Kd : 2.2 μl/mg protein/30 s). Transport of loxoprofen in Caco-2 cells is, at least in part, mediated by a proton-dependent transport system^[5].