MDM2
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB12684 | SP 141 | 1253491-42-7 | SP-141 is a MDM2 inhibitor. It acts by exerting excellent in-vitro and in-vivo anticancer activity. |
| FB04953 | SJ-172550 | 431979-47-4 | SJ-172550 is a small molecule inhibitor of MDMX and competes for the wild type p53 peptide binding to MDMX with an EC50 of 5 μM. |
| FB02718 | SAR405838 | 1303607-60-4 | SAR405838 is a highly potent and selective MDM2 inhibitor, binds to MDM2 with Ki= 0.88 nM and has high specificity over other proteins. |
| FB02725 | RO8994 | 1309684-94-3 | RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). |
| FB00687 | RG7388 | 1229705-06-9 | RG7388 is a potent and selective p53–MDM2 inhibitor which can block the binding of MDM2 to p53 with IC50 value of 30 nM. |
| FB01634 | RG7112 | 939981-39-2 | RG7112 is a small-molecule MDM2 antagonist which can occupy the p53-binding pocket of MDM2. |
| FB19655 | PROTAC MDM2 Degrader-3 | 2249750-23-8 | PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. |
| FB09268 | PK11195 | 85532-75-8 | PK11195 is a 2‑Phenylindolylglyoxylyldipeptide Murine Double Minute2 (MDM2)/Translocator Protein (TSPO)/Human Constitutive Androstane Receptor (hCAR) Inhibitor, and is potentially useful for the Treatment of Gliomas. |
| FB17718 | peptide C19 | 2413879-97-5 | p53/MDM2 peptide C19 is a stapled peptide targeting p53/MDM2 interaction which could increase p53 activity. Its activity and toxicity is highly dependent on the match-up with a specific peptide sequence variant. |
| FB10101 | NVP-CGM097 Stereoisomer | 2070009-54-8 | NVP-CGM097 stereoisomer is a stereoisomer of NVP-CGM097. |
| FB02731 | NVP-CGM097 | 1313363-54-0 | NVP-CGM097 is a potent, selective and species specific p53-Mdm2 inhibitor with IC50 of 1.7±0.1 nM. |
| FB01123 | Nutlin 3b | 675576-97-3 | Nutlin 3b is a MDM2/p53 antagonist or inhibitor with IC50 of 13.6 μM. |
| FB01122 | Nutlin 3a | 675576-98-4 | Nutlin 3a is an improved MDM2-p53 interation antagonist thus acting as p53 (TP53) activator and stabilizer. It is a more potent diastereoisomer of Nutlin-3. |
| FB03817 | Nutlin 3(Random Configuration) | 890090-75-2 | Nutlin 3(Random Configuration) is an MDM2 antagonist which can activate p53 pathway through inhibition of p53-MDM2 interaction. |
| FB09952 | Nutlin 3 | 548472-68-0 | Nutlin 3 is an MDM2 antagonist which can activate p53 pathway through inhibition of p53-MDM2 interaction. |
| FB08477 | NSC 66811 | 6964-62-1 | NSC 66811 is a potent MDM2 inhibitor with Ki value of 120 nM which can disrupt MDM2-p53 interaction and activate p53 function. |
| FB01662 | NSC 59984 | 803647-40-7 | NSC 59984 is a reactivator of p53 which targets various mutant p53 to restore wild-type p53 pathway via the activation of p73 in cancer cells. It could induce p53 mutant protein degradation via MDM2-mediated ubiquitination. |
| FB10022 | MX69 | 1005264-47-0 | MX69 is a dual inhibitor of MDM2 and XIAP which can induce MDM2 downregulation resulted not only in inhibition of XIAP expression, but also in activation of p53. |
| FB17203 | MD-224 | 2136247-12-4 | MD-224 is a potent small-molecule MDM2 degrader which induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. |
| FB11061 | NVP-HDM 201 | 1448867-41-1 | HDM201 binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction of the two proteins and leading to the activation of the p53 pathway. It induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells. HDM201 exhibits highly selectivity across a panel of cancer cell lines. |
| FB11532 | DS-3032b | 2095625-97-9 | DS-3032b is an orally available MDM2 (murine double minute 2) antagonist with potential antineoplastic activity. |
| FB10929 | BI-0252 | 1818291-27-8 | BI-0252 is a chemically stable and orally active inhibitors of the MDM2-p53 interaction. |
| FB10066 | APG-115 | 1818393-16-6 | APG-115 is a compound with a very high affinity to MDM2 (Ki < 1 nM), potent cellular activity, and an excellent oral pharmacokinetic profile. |
| FB17725 | AcSAHp 538 | 932726-25-5 | AcSAHp 538 is a stabilized alpha-helix of p53 peptide that exhibits high affinity for hDM2. It reactivated the p53 tumor suppressor cascade by inducing the transcription of p53-responsive genes. Treatment with AcSAHp 538 led specific, dose-dependent cytotoxicity and apoptosis induction in SJSA-1 cells. |