PARP
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00254 | XAV-939 | 284028-89-3 | XAV-939 is a selective Wnt pathway β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 values of 11 and 4 nM for the inhibition of TNKS1 and TNKS2, respectively. |
| FB08327 | WIKI4 | 838818-26-1 | WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) and inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM). |
| FB01817 | Veliparib | 912444-00-9 | Veliparib is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. |
| FB01816 | Veliparib 2HCl | 912445-05-7 | Veliparib 2HCl is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. |
| FB00962 | UPF-1069 | 1048371-03-4 | UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM, which is ~27-fold selective against PARP1. |
| FB11193 | TNKS Inhibitor C41 | 1584646-42-3 | Tankyrase inhibitor C41 is a highly selective Tankyrase inhibitor displaying growth inhibition effects against a diverse range of tumor derived cell lines |
| FB01651 | Rucaparib Phosphate | 459868-92-9 | Rucaparib phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
| FB01826 | Rucaparib | 283173-50-2 | Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
| FB15403 | RK-287107 | 2171386-10-8 | RK-287107 is a novel tankyrase-specific inhibitor with IC50 values of 14.3 nM and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. |
| FB17648 | RBN-2397 | 2381037-82-5 | RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores IFN signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors . |
| FB01129 | PJ34 | 344458-19-1 | PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively. |
| FB00369 | PJ34 HCl | 344458-15-7 | PJ34 HCl is a potent specific inhibitor of PARP-l/2 with IC50 of 110 nM and 86 nM. |
| FB08779 | Picolinamide | 1452-77-3 | Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
| FB12638 | Rucaparib Camsylate | 1327258-57-0 | PARP inhibitor |
| FB02423 | Olaparib | 763113-22-0 | Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively. |
| FB10862 | OL-1 | 2051582-06-8 | OL-1 is a PARP1 inhibitor with apoptosis-inducing mechanisms in triple-negative breast cancer. |
| FB07479 | NVP-TNKS656 | 1419949-20-4 | NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, showing > 300 fold selectivity against PARP1 and PARP2. |
| FB17976 | Nudifloramide | 701-44-0 | Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro. |
| FB07107 | NU1025 | 90417-38-2 | NU1025 is a potent PARP inhibitor with IC50 of 400 nM. |
| FB10246 | NMS-P118 | 1262417-51-5 | NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor for cancer therapy with an IC50 of 0.04 μM in HeLa cell. |
| FB00380 | MN-64 | 92831-11-3 | MN-64 is an inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition. |
| FB01947 | MK-4827 Tosylate | 1038915-73-9 | MK-4827 tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM and with great activity in cancer cells with mutant BRCA-1 and BRCA-2 and > 330-fold selective against PARP3, V-PARP and Tank1. |
| FB09880 | MK-4827 R-enantiomer | 1038915-58-0 | MK-4827 R-enantiomer is an excellent PARP1 inhibitor with IC50 of 2.4 nM. |
| FB02649 | MK-4827 | 1038915-60-4 | MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 3.8 and 2.1 nM, respectively. |
| FB01946 | MK-4827 HCl | 1038915-64-8 | MK-4827 HCl is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM, showing great activity in cancer cells with mutant BRCA-1 and BRCA-2, and is > 330-fold selective against PARP3, V-PARP and Tank1. |
| FB10181 | ME0328 | 1445251-22-8 | ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1. |
| FB10940 | LT-626 | 1207456-03-8 | LT-626 functions as an effective radiosensitizer during fractionated radiation treatment, leading to significant decrease in tumor burden and doubling the median survival. |
| FB08893 | JW 55 | 664993-53-7 | JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM respectively. |
| FB03413 | INO-1001 | 3544-24-9 | INO-1001 is a potent inhibitor of PARP with IC50 of < 50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion. |
| FB15649 | GeA-69 | 2143475-98-1 | GeA-69 is a selective PARP14 inhibitor with Kd value of 2.1 µM, targeting on macrodomain 2. |
| FB02818 | G007-LK | 1380672-07-0 | G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS1/2, respectively. |
| FB02289 | E-7449 | 1140964-99-3 | E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2 and enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. |
| FB16481 | BYK204165 | 1104546-89-5 | BYK204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). |
| FB01849 | BSI-201 | 160003-66-7 | BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). |
| FB08614 | BMN-673 | 1207456-01-6 | BMN-673 is a PARP1/2 inhibitor with IC50 of 0.57 nM for PARP1. |
| FB02319 | BMN-673 8R,9S | 1207456-00-5 | BMN-673 8R,9S is an enantiomer of BMN-673, which is a PARP1/2 inhibitor with IC50 of 0.57 nM for PARP1. |
| FB07028 | BGP-15 | 66611-37-8 | BGP-15, is a nicotinic amidoxime derivative with PARP inhibitory activity. It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury. |
| FB00358 | Pamiparib | 1446261-44-4 | BGB-290 shows potent DNA-trapping activity with IC50 of 13 nM. In the cellular assays, BGB-290 inhibits intracellular PAR formation with an IC50 of 0.24 nM. |
| FB08022 | Benzamide | 55-21-0 | Benzamide, an inhibitor of poly (ADP-ribose) polymerase, is a derivative of benzoic acid. |
| FB03529 | AZD2461 | 1174043-16-3 | AZD2461 is a PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by Pgp. |
| FB18226 | AZ9482 | 1825345-33-2 | AZ9482 is a PARP inhibitor with IC50 values of 1, 1, 46, 640, 9, and 160nM for PARP1, -2, -3, -6, TNKS1/PARP5a, and TNKS2, respectively. |
| FB03963 | AZ6102 | 1645286-75-4 | AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells. |
| FB09989 | AZ1366 | 1645286-58-3 | AZ1366 inhibits tankyrase as a cotreatment strategy with EGFR inhibition in an identifiable subset of EGFR-driven NSCLC. |
| FB01154 | AG-14361 | 328543-09-5 | AG14361 is a potent inhibitor of PARP1 with Ki of < 5 nM. |
| FB01809 | A-966492 | 934162-61-5 | A-966492 is a potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. |
| FB12579 | 4-HQN | 491-36-1 | 4-HQN is a PARP inhibitor with IC50 of 9.5 μM. |
| FB12937 | 3-Methoxybenzamide | 5813-86-5 | 3-Methoxybenzamide is a competitive poly(ADP-ribose) synthetase inhibitor with Ki value < 2 μM and also inhibits ADP-ribosyltransferase (ADPRT). |