HIV Integrase
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB01291 | Raltegravir Potassium | 871038-72-1 | Raltegravir Potassium is an HIV integrase strand transfer inhibitor which acts as the first of the class of antiviral agents active against the human immunodeficiency virus (HIV). |
| FB01290 | Raltegravir | 518048-05-0 | Raltegravir is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human α-, β-, γ-polymerases. |
| FB05739 | MK-2048 | 869901-69-9 | MK-2048 is a potent inhibitor of integrase and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. |
| FB07167 | HIV-1 Integrase Inhibitor 2 | 957890-42-5 | HIV-1 integrase inhibitor, in the treatment of human immunodeficiency virus (HIV) infection. |
| FB17915 | HIV-1 integrase inhibitor 8 | 1568-80-5 | HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8. |
| FB11831 | HIV-1 Integrase Inhibitor 4 | 1638504-66-1 | HIV-1 integrase inhibitor 4 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 3.7 nM. |
| FB11832 | HIV-1 Integrase Inhibitor 3 | 1638504-56-9 | HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM. |
| FB00161 | Elvitegravir | 697761-98-1 | Elvitegravir is a quinolinemonocarboxylic-acid HIV-1 integrase strand transfer inhibitor used to treat HIV infection. It is also a cytochrome P450 2C9 inducer. |
| FB07944 | Dolutegravir Sodium | 1051375-19-9 | Dolutegravir sodium is an HIV integrase inhibitor (IC50= 2.7 nM) with modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. |
| FB08209 | Dolutegravir | 1051375-16-6 | Dolutegravir is an integrase inhibitor (IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. |
| FB10706 | Cichoric Acid | 6537-80-0 | Cichoric Acid is a naturally occuring phenylpropanoid found in a variety of plants, used as an HIV Integrase inhibitor. |
| FB02433 | Cabotegravir | 1051375-10-0 | Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Cabotegravir is an inhibitor of OAT1 (IC50 0.81 μM) and OAT3 (IC50 0.41 μM). |
| FB06265 | BMS-707035 | 729607-74-3 | BMS-707035 is a potent, specific, reversible HIV-I integrase inhibitor with IC50 value of 15 nM. |
| FB01588 | BMS-538203 | 543730-41-2 | BMS-538203 is a highly efficient HIV integrase inhibitor and antiviral agent. |
| FB11255 | Bictegravir | 1611493-60-7 | Bictegravir is a potent, unboosted, once-Daily HIV-1 Integrase Strand Transfer inhibitor (INSTI) (IC50 - 1.6 nM) with improved pharmacokinetics and in vitro resistance profile. |
| FB02293 | BI-224436 | 1155419-89-8 | BI-224436 is an HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains. |
| FB03187 | (±)-BI-D | 1416258-16-6 | (±)-BI-D is a potent ALLINI (An allosteric IN inhibitor) that binds integrase at the LEDGF/p75 binding site. |