sEH is a member of the epoxide hydrolase family. This enzyme, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding diols.
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB12936 | TPPU | 1222780-33-7 | TTPU is an inhibitor of epoxide hydrolase (sEH) with IC50 of 3.7 nM with anti-inflammatory and anti-atherosclerotic activities. |
| FB16847 | PTUPB | 1287761-01-6 | PTUPB is a novel dual COX2 and sHE (soluble epoxide hydrolase) inhibitor. Treatment with PTUPB reduced body weight, liver weight, liver triglyceride and cholesterol content, and the expression of lipolytic/lipogenic and lipid uptake related genes (Acc, Cd36, and Cidec) in HFD mice. This made it be a promising potential therapy for liver steatosis associated with obesity. |
| FB16479 | EC5026 | 1809885-32-2 | EC5026 is a first-in-class, small molecule that potently inhibits soluble Epoxide Hydrolase (sEH), a key regulatory enzyme involved in the metabolism of membrane fatty acids. |
| FB16493 | AUDA | 479413-70-2 | AUDA is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively and with anti-inflammatory activity. |