VEGFR
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB04044 | ZM323881 HCl | 193000-39-4 | ZZZM 323881 HCl is a potent and selective VEGFR2 inhibitor with IC50 of < 2 nM, almost no activity on VEGFR1, PDGFRβ, FGFR1, EGFR and ErbB2. |
| FB04409 | XL647 | 781613-23-8 | XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity. |
| FB18852 | XL-092 | 2367004-54-2 | XL-092 is an ATP-competitive inhibitor of multiple receptor tyrosine kinases including MET, VEGFR2, AXL and MER, with IC50 values of 15, 1.6, 3.4, and 7.2 nM, respectively, in cell-based assays. |
| FB11001 | VEGFR Inhibitor TC2 | N/A | VEGFR inhibitor TC2 is a 4-epi-analog of tobacco cembranoid VEGFR inhibitor TC1 acts in angiogenesis inhibitory in multiple breast cancer cell lines by significantly reducing the activated VEGFR2 levels. |
| FB11000 | α-Cembrenediol | 57605-80-8 | VEGFR inhibitor TC1 acts in angiogenesis inhibitory in multiple breast cancer cell lines by significantly reducing the activated VEGFR2 levels. |
| FB04907 | Vandetanib Trifluoroacetate | 338992-53-3 | Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM. |
| FB06176 | Vandetanib HCl | 524722-52-9 | Vandetanib HCl specially inhibits VEGFR2 with IC50 of 40 nM. |
| FB16533 | Tyrphostin AG1433 | 168835-90-3 | Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. |
| FB01926 | TG 100801 HCl | 1018069-81-2 | TG 100801 is the prodrug of TG 100572, which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM or VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. |
| FB11167 | SU5408 | 15966-93-5 | SU5408 is a VEGFR2 kinase inhibitor with IC50 of 70 nM in murine. |
| FB11669 | SU5208 | 62540-08-3 | SU5208 is an analogue of SU5025. |
| FB09929 | Su5205 | 3476-86-6 | Su5205 is an inhibitor of VEGFR2. |
| FB08304 | SU14813 | 452105-23-6 | SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like tyrosine kinase 3 (FLT-3) |
| FB11201 | SU-10994 | 748153-84-6 | SU-10994 is a VEGFR inhibitor with potential anticancer activity. |
| FB09928 | SU 4312 | 5812-07-7 | SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively), which is selective over EGFR and c-Src tyrosine kinases. |
| FB01135 | SKLB1002 | 1225451-84-2 | SKLB1002 is a selective inhibitor of VEGFR2 with IC50 of 32 nM. |
| FB16357 | SCR-1481B1 x(NH2(OH)3) | N/A | SCR-1481B1 is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor. |
| FB03221 | SAR131675 | 1433953-83-3 | SAR131675 is selective inhibitor of VEGFR3 with IC50 and Ki of 23 nM, 12 nM, respectively. |
| FB07151 | SAR131675 Racemate | 1092539-44-0 | SAR131675 is a selective inhibitor of VEGFR-3 (IC50 = 20 nM) with antitumoral and antimetastatic activities. |
| FB07548 | Regorafenib Monohydrate | 1019206-88-2 | Regorafenib is a multi-target inhibitor. It can inhibit the activities of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 and their IC50 values range from 1.5 nM to 46 nM. |
| FB01151 | Regorafenib HCl | 835621-07-3 | Regorafenib HCl can inhibit many kinases including RET (IC50 = 1.5 nM), Raf-1 (IC50 = 2.5 nM), VEGFR2 (IC50 = 4.2 nM), VEGFR1 (IC50 = 13 nM), PDGFRβ (IC50 = 22 nM) and VEGFR3 (IC50 = 46 nM). |
| FB06893 | R1530 | 882531-87-5 | R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities. |
| FB12420 | Vatalanib Succinate | 212142-18-2 | Potent VEGFR inhibitor; also aromatase inhibitor |
| FB16384 | ODM-203 | 1430723-35-5 | ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively. |
| FB04918 | N-Desethyl Sunitinib | 356068-97-8 | N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib, which is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT respectively). |
| FB01394 | Motesanib Diphosphate | 857876-30-3 | Motesanib diphosphate is ATP-competitive inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50 of 2 nM, 3 nM and 6 nM, respectively. It also shows better inhibitory activity against c-Kit, PDGFR, and RET. |
| FB03368 | Lenvatinib Mesylate | 857890-39-2 | Lenvatinib mesylate is an inhibitor of VEGFR2 with potential antineoplastic activity. It can decrease vascular endothelial cell migration and proliferation. |
| FB01395 | Ki8751 | 228559-41-9 | Ki8751 is a selective VEGFR2 inhibitor with IC50 of 0.9 nM. |
| FB17298 | JNJ-38158471 | 951151-97-6 | JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively . |
| FB12755 | ZM 306416 HCl | 196603-47-1 | Inhibitor of VEGF receptor tyrosine kinase |
| FB18256 | GW806742X | 579515-63-2 | GW806742X is an ATP mimetic MLKL inhibitor with Kd value of 9.3μM, and a VEGFR2 inhibitor with IC50 value of 2nM. |
| FB02335 | Fruquintinib | 1194506-26-7 | Fruquintinib is an inhibitor of VEGFR family with IC50s of 33 nM, 35 nM and 0.5 nM for VEGFR1, 2, 3 respectively. |
| FB02361 | EG00229 | 1210945-69-9 | EG00229 is the first small molecule inhibitor of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 μM(125I-VEGF binding to PAE/NRP1 cells). |
| FB01975 | E-3810 | 1058137-23-7 | E-3810 is a dual inhibitor of the VEGF and FGF receptors, potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 with IC50 of 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively. |
| FB18055 | Donafenib | 1130115-44-4 | Donafenib, also known as CM-4307, is a multikinase inhibitor of Raf kinase and receptor tyrosine kinases with IC50 of 6 nM, 20 nM and 22 nM for Raf-1, B-Raf and VEGFR-3, respectively. |
| FB16881 | DMH4 | 515880-75-8 | DMH4 is a selective inhibitor of VEGFR-2 with IC50 of 161 nM. |
| FB17215 | Decursin | 5928-25-6 | Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. It inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2. |
| FB02477 | Cediranib Maleate | 857036-77-2 | Cediranib maleate is a highly potent VEGFR (KDR) inhibitor with IC50 of < 1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and > 1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3. |
| FB15754 | Cediranib | 288383-20-0 | Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively. |
| FB02572 | BMS-817378 | 1174161-69-3 | BMS-798433 shows greater than 50% TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model. |
| FB07143 | BMS-690514 | 859853-30-8 | BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kinases. |
| FB16883 | BMS 605541 | 639858-32-5 | BMS 605541 is an ATP-competitive inhibitor of VEGFR-2 with IC50 of 23 nM. |
| FB10139 | BFH772 | 890128-81-1 | BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM. |
| FB10140 | BAW2881 | 861875-60-7 | BAW2881 is an inhibitor of vascular endothelial growth factor (VEGF) with IC50s of 1.0 nM-4.3 nM against VEGFR1, 2, 3 and also inhibits PDGFRβ, c-Kit, and RET. |
| FB02372 | Apatinib Mesylate | 1218779-75-9 | Apatinib Mesylate is a VEGFR2 inhibitor with IC50 of 1 nM and also can suppress the activities of Ret (IC50 = 13 nM), c-Kit (IC50 = 429 nM) and c-Src (IC50 = 530 nM). |
| FB11684 | SU5204 | 186611-11-0 | Analogue of SU5025 |
| FB15382 | Acrizanib | 1229453-99-9 | Acrizanib is a selective VEGFR2 inhibitor with IC50 value of 17.4nM. |
| FB13021 | 4,4-Bis(4-aminophenoxy)biphenyl | 13080-85-8 | 4,4'-Bis(4-aminophenoxy)biphenyl is a potent Flk-1 (VEGFR2) inhibitor. |
| FB02518 | 2,4-Pyrimidinediamine with Linker | 1430089-64-7 | 2,4-Pyrimidinediamine with linker is a multikinase inhibitor with a -NH2 terminal linker. |
| FB16882 | (E)-FeCP-oxindole | 884338-18-5 | (E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) with IC50 of 214 nM. |