CAS:85801-02-1Indomethacin Farnesil

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Indometacin farnesil is a prodrug of the non-steroidal anti-inflammatory drug indometacin.

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描述Indomethacin farnesil (IMF) is a novel prodrug of indomethacin and has antiinflammatory effects. In the air pouch carrageenin-induced inflammation, an oral dose of IMF exerted dose dependent inhibitory effects on the accumulation of inflammatory exudate fluid and the migration of leukocytes into the exudate. In spite of the inability of IMF to inhibit prostaglandin synthesis in a cell free cyclooxygenase system, IMF injected locally inhibited carrageenin paw edema, and the inhibitory effect was comparable to that of indomethacin itself^[3]. Moreover, indomethacin farnesil was effective for myalgia and also decreased the number of CD16(+) CD56(-) NK cells^[4].