K-Ras (G12C)/PROTAC refers to the PROTAC target K-Ras (G12C).
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB19608 | PROTAC K-Ras Degrader-1 | 2378258-52-5 | PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC targeting on K-Ras and exhibits ≥70% degradation efficacy in SW1573 cells. |
| FB17542 | LC-2 | 2502156-03-6 | LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines. |