P2X Receptor
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00221 | Ro 51 | 1050670-85-3 | Ro 51 is a potent, dual P2X3 and P2X2/3 antagonist (IC50 values are 2 and 5 nM for rP2X3 and hP2X2/3 respectively). |
| FB02971 | BzATP Triethylammonium Salt | 112898-15-4 | Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase. |
| FB11758 | BzATP | 81790-82-1 | Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase. |
| FB08834 | NF449 | 627034-85-9 | NF449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist. |
| FB11235 | NF023 | 104869-31-0 | NF023, a subtype-selective, competitive and reversible P2X1 receptor antagonist, displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. |
| FB03134 | KN-62 | 127191-97-3 | KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM.. |
| FB11020 | JNJ-54175446 | 1627902-21-9 | JNJ-54175446 is a potent and selective P2X7 Receptor Antagonist. |
| FB01398 | JNJ 47965567 | 1428327-31-4 | JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). |
| FB04879 | GW791343 3HCl | 309712-55-8 | GW791343 3HCl is a P2X7 allosteric modulator and exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). |
| FB02444 | GW791343 2HCl | 1019779-04-4 | GW791343 2HCl is a P2X7 allosteric modulator exhibiting species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). |
| FB12010 | Gefapixant | 1015787-98-0 | Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. |
| FB00143 | CTP Disodium Dihydrate | 81012-87-5 | CTP Disodium Dihydrate is a P2X4 purinergic receptor agonist. |
| FB11795 | CE-224535 | 724424-43-5 | CE-224535 is a selective P2X7 receptor antagonist. |
| FB16521 | BX430 | 688309-70-8 | BX430 is selective P2X4 allosteric antagonist with IC50 of 0.54 μM. |
| FB10335 | AZD9056 HCl | 345303-91-5 | AZD9056 HCl is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. |
| FB18028 | AZ10606120 2HCl | 607378-18-7 | AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth . |
| FB05340 | AF-353 | 865305-30-2 | AF-353 is a potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0). |
| FB06880 | A 839977 | 870061-27-1 | A-839977 is a selective P2X7 antagonist and blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). |
| FB10328 | A-804598 | 1125758-85-1 | A-804598 is a competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
| FB02108 | A-740003 | 861393-28-4 | A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). |
| FB10332 | A-317491 Sodium Hydrate | N/A | A-317491 sodium is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. |
| FB06150 | A-317491 | 475205-49-3 | A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors. |
| FB06917 | A 438079 | 899507-36-9 | A 438079 is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). |
| FB06916 | A 438079 HCl | 899431-18-6 | A 438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line). |