MEK
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10187 | Vacquinol-1 2HCl | 1998099-96-9 | Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death. |
| FB07458 | U0126 | 109511-58-2 | U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. |
| FB00754 | U0126 Ethanol | 1173097-76-1 | U0126 ethanol is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM. |
| FB03776 | Trametinib | 871700-17-3 | Trametinib is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. |
| FB01549 | Trametinib DMSO Solvate | 1187431-43-1 | Trametinib DMSO Solvate is a specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM. |
| FB03727 | TAK-733 | 1035555-63-5 | TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. |
| FB09341 | SL327 | 305350-87-2 | SL327 is a cell-permeable vinylogous cyanamide that acts as a selective inhibitor of MEK-1 and MEK-2 (IC50 = 0.18 and 0.22 μM respectively). |
| FB03815 | Selumetinib | 606143-52-6 | Selumetinib is a potent, highly selective MEK1 inhibitor with IC50 of 14 nM, also inhibits ERK1/2 phosphorylation with IC50 of 10 nM, no inhibition to p38α, MKK6, EGFR, ErbB2, ERK2, B-Raf, etc. |
| FB07526 | RO4987655 | 874101-00-5 | RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity. |
| FB06948 | Refametinib R-Enantiomer | 923032-38-6 | Refametinib R-enantiomer is the only cyclopropane-1-sulfonamide derivative, and exhibits a highly selective allosteric inhibition of MEK 1/2. |
| FB06947 | Refametinib | 923032-37-5 | Refametinib is a specific and non-ATP-competitive MEK 1/2 inhibitor with IC50 values of 19 and 47 nM, respectively. |
| FB08625 | PF-3644022 | 1276121-88-0 | PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM and Ki = 3 nM). It inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM) and exhibits oral efficacy in acute and chronic inflammatory models. |
| FB08037 | PD98059 | 167869-21-8 | PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK and does not directly inhibit ERK1 or ERK2. |
| FB06141 | PD318088 | 391210-00-7 | PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. |
| FB10781 | PD-184161 | 212631-67-9 | PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. |
| FB08540 | PD0325901 | 391210-10-9 | PD0325901 is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
| FB12486 | PD 334581 | 548756-68-9 | PD 334581 is an inhibitor of MEK1. |
| FB02757 | OTS-964 | 1338545-07-5 | OTS-964 is a TOPK (T-LAK cell originated protein kinase) inhibitor with IC50 value of 28 nM, which can specifically block cytokinesis, leading to apoptosis, in a broad range of cancer cells. |
| FB03998 | NQDI-1 | 175026-96-7 | NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with IC50 of 3 μM and Ki of 500 nM. |
| FB12464 | MSC 2032964A | 1124381-43-6 | MSC 2032964A is a potent and selective ASK1 inhibitor with IC50 of 93 nM. |
| FB11783 | MKI 833 | 863029-99-6 | MKI 833 is a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway. |
| FB18844 | MK2-IN-3 | 724711-21-1 | MK2 Inhibitor III is a potent and selective MK-2 inhibitor with IC50 value of 8.5nM. |
| FB10861 | MEK1 Inhibitor CL2 | 40784-65-4 | MEK1 inhibitor CL2 exhibits MEK1 binding affinity with IC50 71 nM, which is so far the best result for metal complexes and more potent than U0126(7.02 μM) and AZD6244(2.20 μM). |
| FB04904 | MEK Inhibitor | 334951-92-7 | MEK inhibitor is a potent MEK inhibitor, antitumor agent. |
| FB12255 | HI TOPK 032 | 487020-03-1 | HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor. |
| FB16055 | 6,7-Dimethoxy-N-(3-phenoxyphenyl)quinolin-4-amine hydrochloride | 179246-08-3 | GW284543 HCl is a selective MEK5 inhibitor. It reduces pERK5 and decreases endogenous MYC protein. |
| FB02616 | GDC-0623 | 1168091-68-6 | GDC-0623 is a selective and ATP-uncompetitive MEK1 inhibitor with Ki value of 0.13 nM. |
| FB02997 | DTP3 | 1809784-29-9 | DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-κB survival pathway. |
| FB06967 | Cobimetinib R-Enantiomer | 934660-94-3 | Cobimetinib R-enantiomer is the R-enantiomer of cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase (MEK1/2). |
| FB06968 | Cobimetinib Racemate | 934662-91-6 | Cobimetinib is a potent, highly selective inhibitor of MEK1/2. |
| FB07939 | Cobimetinib | 934660-93-2 | Cobimetinib is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. |
| FB04224 | CI-1040 | 212631-79-3 | CI-1040 is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM, being 100-fold selective for MEK1/2 than MEK5. |
| FB02693 | BIX-02189 | 1265916-41-3 | BIX02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. |
| FB09933 | BIX-02189(Random Configuration) | 1094614-85-3 | BIX-02189(Random Configuration) is a selective and potent inhibitor of both MEK5 and ERK5 with IC50 values of 1.5 and 59 nM, respectively. |
| FB09935 | BIX-02188(Random Configuration) | 1094614-84-2 | BIX-02188(Random Configuration) is a potent and selective MEK5 inhibitor with IC50 value of 4.3 nM. |
| FB05352 | BIX-02188 | 334949-59-6 | BIX-02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
| FB08063 | AZD8330 | 869357-68-6 | AZD8330 is a selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. |
| FB12705 | TC ASK 10 | 1005775-56-3 | ASK1 Inhibitor 10 is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1). It is selective for ASK1 over ASK2 as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF. It inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner. |
| FB08837 | AS-703026 | 1236699-92-5 | AS7-03026 is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. |
| FB08831 | ARRY-162 | 606143-89-9 | ARRY-162 is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. |
| FB10305 | APS-2-79 HCl | 2002381-31-7 | APS-2-79 HCl is a KSR (Kinase suppressor of Ras)-dependent MAPK modulator which can stabilize KSR inactive state with an IC50 value of 120 nM, resulting in inhibition of oncogenic Ras signaling, antagonizing the Ras–MAPK pathway. |