STAT
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB10841 | STX-0119 | 851095-32-4 | STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. |
| FB06768 | Stattic | 19983-44-9 | Stattic, a nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. |
| FB10826 | STAT5 Inhibitor | 285986-31-4 | STAT5 inhibitor suppresses STAT5 via interaction of its SH2 domain with IC50 of 47 µM. |
| FB17917 | STAT3-IN-7 | 1313019-65-6 | STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects. |
| FB17642 | STAT3-IN-1 | 2059952-75-7 | STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis . |
| FB10777 | Stafib-2 | 1688703-26-5 | Stafib-2 selectively inhibits tyrosine phosphorylation of STAT5b in human leukaemia cells and induces apoptosis in a STAT5-dependent manner. |
| FB10213 | STA-21 | 111540-00-2 | STA-21 is a selective STAT3 inhibitor. |
| FB12129 | SH5-07 | 1456632-41-9 | SH5-07 is an inhibitor of STAT3 with IC50 of 3.9±0.6 μM with antitumor effects and it can suppresse human glioma and breast cancer. |
| FB03252 | SH-4-54 | 1456632-40-8 | SH-4-54 is a potent, small molecule, nonphosphorylated STAT3 inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. |
| FB09552 | Saikosaponin D | 20874-52-6 | Saikosaponin D, a natural product isolated and purified from the herb of Bupleurum chinense DC., is a SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity and a potent inhibitor on acute hepatic injury by CCl4 and a potent cytotoxicity agent for human hepatocellular carcinoma cells, and has the antiproliferative effect in A549 cells that may be the induction of p53 and activity of the Fas/FasL apoptotic system. |
| FB08820 | S3I-201 | 501919-59-1 | S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5. |
| FB07564 | Nifuroxazide | 965-52-6 | Nifuroxazide suppresses the transcription activity of STAT1, STAT3 (IC50 = 3 μM in cells) and STAT5. It is a nitrofuran-based antidiarrheal agent that can prevent urinary tract infections. |
| FB02485 | Niclosamide | 50-65-7 | Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibits the phosphorylation of STAT3 and has no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5). |
| FB06304 | Napabucasin | 83280-65-3 | Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3. |
| FB11166 | inS3-54-A18 | 328998-53-4 | inS3-54-A18 is an inhibitor of STAT3 that suppresses tumor growth, metastasis and the expression of STAT3 target genes. |
| FB10320 | HO-3867 | 1172133-28-6 | HO-3867 selectively inhibits the phosphorylation and transcription of STAT3. It is an analog of curcumin. |
| FB12123 | HJC0152 | 1420290-99-8 | HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner. |
| FB12244 | Galiellalactone | 133613-71-5 | Galiellalactone is a STAT3 inhibitor that irreversibly binds STAT3 and inhibits binding to DNA. |
| FB06745 | Cryptotanshinone | 35825-57-1 | Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM. |
| FB05169 | Corylifol A | 775351-88-7 | Corylifol A is a phenolic compounds isolated from Psoralea corylifolia and inhibits IL-6-induced STAT3 activation and phosphorylation (IC50=0.8 μM). |
| FB17598 | Colivelin TFA | N/A | Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury . |
| FB12919 | Colivelin | 867021-83-8 | Colivelin is a peptide and activator of STAT3 with neuroprotective effects. |
| FB11016 | C188-9 | 432001-19-9 | C188-9 is a STAT3 inhibitor and has no effects on non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in mice. |
| FB05260 | Brevilin A | 16503-32-5 | Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM). |
| FB01631 | BP-1-102 | 1334493-07-0 | BP-1-102 is an orally available, small-molecule inhibitor of transcription factor STAT3. |
| FB19575 | AZD 9150 | 1402357-06-5 | AZD9150 is an antisense oligonucleotide inhibitor of STAT3. |
| FB00619 | AS-1517499 | 919486-40-1 | AS-1517499 is a potent STAT6 inhibitor with IC50 of 21 nM. |