eIF
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB12780 | SBI-0640756 | 1821280-29-8 | SBI-0640756 is an inhibitor of eIF4G1 which can disrupt the function of eIF4F complex. |
| FB10045 | 6-Chloro-3-[3-(5-fluoropyridin-3-yl)acryloyl]-4-phenyl-1H-quinolin-2-one | 1997370-71-4 | SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling. |
| FB00653 | Briciclib | 865783-99-9 | Briciclib is a small molecule that suppresses cyclin D1 accumulation in cancer cells. |
| FB04888 | 4EGI-1 | 315706-13-9 | 4EGI-1 is an inhibitor of the cap-dependent translation initiation through disturbing the interaction between eIF4E and eIF4G, HNE1 cell line is the most sensitive one to 4EGI-1, and the IC50 of 4EGI-1 was about 50μM at 72h. |
| FB04897 | 4E1RCat | 328998-25-0 | 4E1RCat blocks interaction between eIF4E:eIF4G and eIF4E:4E-BP1, prevents assembly of the eIF4F complex and inhibits cap-dependent translation with IC50 ~4 μM. |