DNA/RNA Synthesis
| 货号 | 产品名 | CAS号 | 信息 |
|---|---|---|---|
| FB00889 | Vidarabine H2O | 24356-66-9 | Vidarabine is an antiviral drug which is active against herpes simplex and varicella zoster viruses. |
| FB12915 | Uridine-5'-triphosphoric acid trisodium salt | 19817-92-6 | Uridine-5'-triphosphoric acid trisodium salt is a pyrimidine nucleoside triphosphate, a substrate for the synthesis of RNA during transcription. |
| FB16740 | 2'-Deoxy-2'-fluorouridine | 784-71-4 | RNA that was modified with 2'-deoxy-2'-fluorouridine yielded full length HIV-1 reverse transcription products, with complete fidelity in transcription. RNA analogue, FF, containing two molecules of 2'-deoxy-2'-alpha-fluorouridine in place of uridine efficiently inhibited the RNase L-catalyzed RNA cleavage reaction. |
| FB11740 | Risdiplam | 1825352-65-5 | Risdiplam is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels. |
| FB11764 | RG7800 HCl | N/A | RG7800 HCl is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; has the potential to treat spinal muscular atrophy. |
| FB17297 | RG7800 | 1449598-06-4 | RG7800 HCl is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; has the potential to treat spinal muscular atrophy. |
| FB00428 | Panaxadiol | 19666-76-3 | Panaxadiol, a natural product isolated and purified from the roots of Panax ginseng C. |
| FB07595 | Nimustine HCl | 55661-38-6 | Nimustine HCl is a nitrosourea alkylating agent with antineoplastic activity. |
| FB16686 | N,N-Dimethylguanosine | 2140-67-2 | N,N-Dimethylguanosine, an urinary nucleoside, is a primary degradation product of tRNA. |
| FB10866 | MS444 | 150045-18-4 | MS-444 is a chrysanthone-like compound specifically inhibit the HuR from binding ARE-RNAs. |
| FB05950 | Mithramycin A | 18378-89-7 | Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action, and inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells. |
| FB12770 | Guanosine | 118-00-3 | Guanosine is a purine nucleoside. |
| FB16690 | L-Guanosine | 26578-09-6 | Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. L-Guanosine is the L configuration of Guanosine. |
| FB20343 | Gemcitabine monophosphate | 116371-67-6 | Gemcitabine is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| FB05010 | Euscaphic Acid | 53155-25-2 | Euscaphic acid, a natural product isolated and purified from the dried fruit of Ziziphus jujuba, with anti-diabetic and anti-inflammatory activities, induces death by activation of caspase-3, dependent apoptotic pathway, and inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction to downregulate NF-κB activations. |
| FB09861 | 2'-Deoxypseudouridine | 39967-60-7 | Deoxypseudouridine is a nucleotide analog. |
| FB02567 | Daptomycin | 103060-53-3 | Daptomycin is a lipopeptide antimicrobial agent with activity against Gram-positive organisms, including multi-resistant strains. |
| FB11363 | CX-5461 HCl | 2101314-20-7 | CX-5461 HCl is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM). |
| FB16439 | CMLD-2 | 958843-91-9 | CMLD-2 competitively binds to Hu antigen R with Ki value of 350nM and disrupts the interaction of HuR and ARE (adenine- and uridine-rich element) of target mRNAs. |
| FB06659 | CBL0137 | 1197996-80-7 | CBL-0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. |
| FB03890 | Blasticidin S HCl | 3513-03-9 | Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA. |
| FB01522 | B02 | 1290541-46-6 | B02 is a RAD51 inhibitor with IC50 of 27.4 μM for human RAD51. |
| FB17804 | AV-153 free base | 19350-66-4 | AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity. |
| FB12958 | Adenine | 73-24-5 | Adenine is a purine derivative and a nucleobase with varieties of biochemistry roles. |
| FB12857 | Adenine HCl | 2922-28-3 | Adenine HCl is a purine derivative and a nucleobase with a variety of biochemistry roles. |
| FB16671 | 2-Amino-8-bromo-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one | 4016-63-1 | 8-Bromoguanosine is a brominated derivative of guanosine. |
| FB16700 | 6-Thioguanosine | 85-31-4 | 6-thioguanosine is photosensitive molecule that photocrosslinks to both proteins and nucleic acids. |
| FB07104 | 6-Mercaptopurine Monohydrate | 6112-76-1 | 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro. |
| FB07229 | 6-Mercaptopurine | 50-44-2 | 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro. |
| FB16145 | 5-Methylcytosine | 554-01-8 | 5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription. |
| FB16130 | 5-Methyl-2'-deoxycytidine | 838-07-3 | 5-Methyl-2'-deoxycytidine (5-Me-dC) is a minor component found in most eukaryotic DNA. |
| FB12880 | 5-methoxyflavone | 42079-78-7 | 5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. |
| FB16725 | 5-Iododeoxycytidine | 611-53-0 | 5-Iododeoxycytidine is used in the construction of DNA oligomers. |
| FB16701 | 5-Iodo-cytidine | 1147-23-5 | 5-Iodocytidine is used for research in the field of nucleic acids and nucleic acid-protein interactions. |
| FB16743 | 5-Fluorouridine | 316-46-1 | 5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity and cytotoxic activity. 5-fluorouridine inhibits rRNA synthesis of human colon carcinoma cells. 5-Fluorouridine exhibits cytotoxic effect on growth of L1210 cells with an IC50 of 2 nM. 5-Fluorouridine triphosphate acted as a potent competitive inhibitor of VPg uridylylation, the initial step of viral replication. |
| FB16708 | 5-Fluorocytidine | 2341-22-2 | 5-Fluorocytidine could replace cytidine and be incorporated into cellular RNAs or tRNAs.The bacterial enzyme cytosine deaminase has been used as a negative selection marker system. Cells that express cytosine deaminase convert 5-fluorocytosine to the toxic compound 5-fluorouracil, and transformed seedlings can thus be identified using medium containing 5-fluorocytosine. |
| FB16692 | 5-Ethynyluridine | 69075-42-9 | 5-Ethynyluridine is used to help detect RNA synthesis in cells by its biosynthetic incorporation into newly transcribed RNA. Once fed to cells, it is incorporated during active RNA synthesis and can then be detected using a copper-catalyzed click reaction with fluorescent dyes. The cells can then be analysed by fluorescence imaging, flow cytometry or high content imaging analysis. |
| FB16717 | 5-Bromouridine | 957-75-5 | 5-Bromouridine is used to label RNA in measurement of RNA production. |
| FB16748 | 5-Bromocytidine | 3066-86-2 | 5-Bromocytidine is a bromine substituted nucleoside.Its β-isomer derivative is a potent anti-HIV agent. |
| FB17824 | 3,4-Dihydroxybenzylamine hydrobromide | 16290-26-9 | 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits DNA polymerase activity in melanoma cells. 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity. |
| FB16676 | 3'-O-Acetylthymidine | 21090-30-2 | 3'-O-Acetylthymidine is a useful modified nucleoside. |
| FB16688 | 3'-O-(TBDMS)Thymidine | 40733-27-5 | 3'-O-(TBDMS)Thymidine is a useful modified nucleoside. |
| FB16675 | 2-O-Methylguanosine | 2140-71-8 | 2'-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine as a substrate. |
| FB16689 | 2'-O-(2-Methoxyethyl)-guanosine | 473278-54-5 | 2'-O-(2-Methoxyethyl)-guanosine is a guanosine derivative as building blocks for cross-linking oligonucleotides. |
| FB13139 | 2'-deoxyuridine | 951-78-0 | 2'-Deoxyuridine is frequently halogenated to create thymidine analogues which is useful in studies of DNA synthesis and degradation mechanisms. |
| FB12954 | 2'-Deoxycytidine | 951-77-9 | 2'-Deoxycytidine, a deoxyribonucleoside, can be used to synthesis DNA. It also exhibits inhibition of growth of cholangiocarcinoma cells. |
| FB16710 | 2'-Deoxyadenosine | 958-09-8 | 2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA. |
| FB16682 | (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diyl diacetate | 3181-38-2 | 2',3',5'-Tri-O-acetylinosine is an intermediate used for the synthesis of 6-substituted purine ribosides. |
| FB16691 | 2-Amino-9-((2R,4R,5S)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one | 22837-44-1 | |
| FB16695 | N-Isobutyrylguanosine | 64350-24-9 |